Results 161 to 170 of about 127,473 (295)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Impairment of lysosomal quality control in Huntington disease. [PDF]

Cell Death Dis
Rusmini P, Mina F, Valenza M, Vitali M, Ferrari V, Tedesco B, Casarotto E, Cozzi M, Chierichetti M, Mohamed A, Pramaggiore P, Cornaggia L, Milioto C, Brodnanova M, Magdalena R, Koshal P, Piccolella M, Cristofani R, Galbiati M, Crippa V, Poletti A.   +20 more
europepmc   +1 more source

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Animal fluency in people with Parkinson's disease: Item‐based performance before and after deep brain stimulation surgery

Journal of Neuropsychology, EarlyView.
Abstract People with Parkinson disease (PD) after surgery for deep brain stimulation (DBS) of the subthalamic nucleus (STN‐DBS) often decline in animal fluency due to impairments in executive functions and/or language. Item‐based measures of animal fluency may shed light on the specific nature of this decline, and into the strategies used when ...
Adrià Rofes, Nikki Janssen, Janine Rook, Eva de Ronde, R. Saman Vinke, Rianne A. J. Esselink, Annelien A. Duits   +6 more
wiley   +1 more source

In Vivo PET Imaging of [¹⁸F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease. [PDF]

J Nucl Med
Zajicek F, Elvas F, Miranda A, Akkermans J, Verhaeghe J, Dominguez C, Doot R, Khetarpal V, Bard J, Liu L, Staelens S, Bertoglio D.   +11 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond. [PDF]

Autophagy Rep
Alshehabi Y, Abrar F, Martin DDO.
europepmc   +1 more source

James Lyman Merrick's Aborted “Mission to the Mohammedans of Persia”

The Muslim World, EarlyView.
Abstract James Lyman Merrick (1803‐1866) served as a missionary of the American Board of Commissioners for Foreign Missions (ABCFM) in Persia between 1835 and 1845. He was America's first missionary to the Muslim world. Based on his field research on the Persians’ religious beliefs, he correctly predicted that the conversion of Persia's Muslims into ...
Hooman Estelami
wiley   +1 more source

Challenging or less challenging oral diadochokinetic tasks-what works best in Huntington disease? A cross-sectional study. [PDF]

J Neurol
Hannemann W, Stahuber L, Kouba T, Lindenberg KS, Rapp D, Lewerenz J, Huppertz HJ, Tykalova T, Rusz J, Landwehrmeyer GB, Mühlbäck A.   +10 more
europepmc   +1 more source

Humanistic Burden of Huntington Disease: Evidence From the Huntington Disease Burden of Illness Study. [PDF]

Neurol Clin Pract, 2022
Rodriguez Santana I, Frank S, Doherty M, Willock R, Hamilton J, Hubberstey H, Stanley C, Vetter L, Winkelmann M, Dolmetsch RE, Li N, Ratsch S, Ali TM.   +12 more
europepmc   +1 more source