Results 11 to 20 of about 9,364,929 (305)
Predictors of persistence and adherence to deutetrabenazine among patients with Huntington disease or tardive dyskinesia [PDF]
Mental Health Clinician, 2023 Introduction Deutetrabenazine is approved for treatment of Huntington disease (HD)-related chorea and tardive dyskinesia (TD) in adults. Factors associated with deutetrabenazine persistence and adherence are not well understood.
Claassen Daniel O. MD +4 more
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Computer Methods and Programs in Biomedicine Update, 2023 Background: Unawareness of Huntington disease is prevalent where patients might have a denial of illness, less reporting of symptoms such as changes in behavior or cognitive impairment, or poor coping with the disease.
Nawal H Alharthi +2 more
doaj +1 more source
Brain hypometabolism in rare genetic neurodegenerative disease: Niemann-Pick disease type C, spinocerebellar ataxia and Huntington disease assessed by FDG PET [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2021 Brain metabolic imaging using 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) with contemporaneous low-dose CT may be used to assess neurodegenerative diseases.
Yung Hsiang Kao +4 more
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Molecular Pathophysiological Mechanisms in Huntington’s Disease
Biomedicines, 2022 Huntington’s disease is an inherited neurodegenerative disease described 150 years ago by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG repeat on exon 1 of the huntingtin gene located on chromosome 4. In the following
Anamaria Jurcău
semanticscholar +1 more source
Brain Communications, 2022 Huntington’s disease is a neurodegenerative disorder involving psychiatric, cognitive and motor symptoms. Huntington’s disease is caused by a tandem-repeat expansion in the huntingtin gene, which is widely expressed throughout the brain and body ...
C. Gubert +12 more
semanticscholar +1 more source
New Avenues for the Treatment of Huntington’s Disease
International Journal of Molecular Sciences, 2021 Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum and cortex.
A. Kim +6 more
semanticscholar +1 more source
Huntington’s disease: diagnosis and management
Practical Neurology, 2021 Huntington’s disease (HD) is an inherited neurodegenerative disease characterised by neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and progressive cognitive impairment. The diagnosis is usually confirmed through identification
T. Stoker +5 more
semanticscholar +1 more source
Principles and Practice of Movement Disorders, 2010 Adult-onset Huntington disease, the most common form of this disorder, usually appears in a person's thirties or forties. Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble learning ...
Joseph Jankovic +5 more
semanticscholar +1 more source
DNA Mismatch Repair and its Role in Huntington’s Disease
Journal of Huntington's Disease, 2021 DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage.
R. Iyer, A. Pluciennik
semanticscholar +1 more source
The Many Facets of Unawareness in Huntington Disease
Tremor and Other Hyperkinetic Movements, 2014 Background: Unawareness or diminished awareness is present when a patient's perception of obvious disease manifestations and impact differ from that of observers such as clinicians or family members.Methods: We examined studies that specifically ...
Elizabeth McCusker, Clement T. Loy
doaj +1 more source