Results 241 to 250 of about 127,576 (299)

Decreased Physical Activity as an Early Digital Biomarker in Huntington's Disease: A One‐Year Observational Study

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Physical Activity: Early Biomarker in Huntington's Disease. ABSTRACT Introduction Huntington's disease (HD) is a neurodegenerative disorder characterised by motor dysfunction, cognitive impairment, and psychiatric disturbances. This study analyzed the relationship between clinical characteristics, sarcopenia, and physical activity (PA) levels in HD ...
Lucía Simón‐Vicente   +6 more
wiley   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu   +1 more
wiley   +1 more source

Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Executive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Simone Migliore   +4 more
wiley   +1 more source

Acute Presentation of Nonpuerperal Uterine Inversion Following a Diagnosis of Uterine Carcinosarcoma: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Nonpuerperal uterine inversion (NPUI) due to endometrial carcinosarcoma can present in an acute manner with life‐threatening complications. The rare presentation of uterine inversion outside of the puerperium caused by a malignant etiology, which was further complicated by the urgent need for intervention, makes this case crucial in ...
Aman Kaur More   +3 more
wiley   +1 more source

Ascertainment of uninterrupted CAG repeat length and disease-modifying variants in fragment-based genetic testing for Huntington Disease. [PDF]

open access: yesGenet Med Open
Findlay Black H   +10 more
europepmc   +1 more source

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