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Irritability in Huntington’s disease
Psychiatry Research, 2012Irritability is a frequent neuropsychiatric symptom in patients with Huntington's disease (HD). The Irritability Scale (IS) and the irritability factor of the Problem Behaviours Assessment (PBA) was used to assess irritability among 130 HD mutation carriers and 43 verified non-carriers. The IS was tested using receiver operating characteristic analysis
Reedeker, N. +6 more
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Care Management Journals, 2008
Huntington's disease (HD) is a hereditary neurodegenerative disorder involving slow, progressive loss of functional capacities. Motor, psychiatric, and cognitive deterioration interfere with activities of independent living, gait, speech, and, ultimately, swallowing.
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Huntington's disease (HD) is a hereditary neurodegenerative disorder involving slow, progressive loss of functional capacities. Motor, psychiatric, and cognitive deterioration interfere with activities of independent living, gait, speech, and, ultimately, swallowing.
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2012
Huntington’s disease (HD) is an autosomal dominantly inherited, fatal neurodegenerative disorder, named for George Huntington, the author of the first definitive report of the condition in 1872. It is characterized by the progressive development of involuntary choreiform movements, although neuropsychiatric symptoms are sometimes the earliest and often
Raphael M, Bonelli, M Flint, Beal
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Huntington’s disease (HD) is an autosomal dominantly inherited, fatal neurodegenerative disorder, named for George Huntington, the author of the first definitive report of the condition in 1872. It is characterized by the progressive development of involuntary choreiform movements, although neuropsychiatric symptoms are sometimes the earliest and often
Raphael M, Bonelli, M Flint, Beal
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The American Journal of Nursing, 1979
ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
J, Stipe, D, White, E, Van Arsdale
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ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
J, Stipe, D, White, E, Van Arsdale
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The Enigma of Huntington's Disease
Scientific American, 2002A description of huntingtons disease and the gene which is responsible for it is presented. Huntingtons disease, which cripples and causes dementia is a genetic disease that results from a mutation in a gene called huntingtin found on chromosome 4. Mutant hutingtin appears to be toxic to key nerve cells in the brain and lacks the ability to turn on a ...
E. Cattaneo, D. Rigamonti, C. Zuccato
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Huntington's disease: Brain imaging in Huntington's disease
2019Huntington's disease (HD) gene-carriers show prominent neuronal loss by end-stage disease, and the use of magnetic resonance imaging (MRI) has been increasingly used to quantify brain changes during earlier stages of the disease. MRI offers an in vivo method of measuring structural and functional brain change. The images collected via MRI are processed
Eileanoir B, Johnson, Sarah, Gregory
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Apoptosis in Huntington's disease
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003Huntington's disease (HD) is an autosomal dominant, fatal disorder. Patients display increasing motor, psychiatric and cognitive impairment and at autopsy, late-stage patient brains show extensive striatal (caudate and putamen), pallidal and cortical atrophy.
Miriam A, Hickey +1 more
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Huntington's disease of early onset or juvenile Huntington's disease
Hospital Medicine, 2003The presentation of juvenile Huntington's disease can cause diagnostic difficulties. The genetics and pathogenesis of the condition are discussed. The diagnosis will depend on the symptoms raising suspicions and the exclusion of other disorders, especially by genetic studies.
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2001
Huntington’s disease is a devastating autosomal-dominant neurodegenerative condition caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. Its epidemiology and clinical features are reviewed. A range of possible mechanisms for the disease is discussed and treatment prospects considered.
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Huntington’s disease is a devastating autosomal-dominant neurodegenerative condition caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. Its epidemiology and clinical features are reviewed. A range of possible mechanisms for the disease is discussed and treatment prospects considered.
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Genetics of Huntington disease
2017In this chapter, we review the evolution of our understanding of the genetic aspects of HD, and the applications of our understanding in the management of Huntington's disease patients and families over the last 150 years. Important aspects of the clinical genetics and epidemiology of Huntington's disease are discussed, such as the definition of ...
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