Results 11 to 20 of about 5,858 (232)

Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent

Frontiers in Pharmacology, 2021
Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools.
P. Khanal, Farshid Zargari, Bahareh Farasati Far, Dharmendra Kumar, M. R, Yasir K. Mahdi, Najwan Jubair, S. Saraf, P. Bansal, Ranjit Singh, Malarvili Selvaraja, Y. Dey   +11 more
semanticscholar   +3 more sources

Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart [PDF]

Molecules, 2020
This is the first report of an efficient and effective procedure to optimize the biosynthesis of huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes. Axenic tissue cultures were established using spores collected from the sporophytes growing in the wild. The prothalia were obtained after 7–18 months. Approximately 90 up
Wojciech J. Szypuła, Beata Wileńska, Aleksandra Misicka, Agnieszka Pietrosiuk   +3 more
openaire   +4 more sources

The pharmacology and therapeutic potential of (-)-huperzine A

Journal of Experimental Pharmacology, 2012
(-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1).
Herzon, Seth, Tun,Maung Kyaw Moe
openaire   +6 more sources

Isolation and purification of Huperzine A

浙江大学学报. 农业与生命科学版, 2002
Technique of isolation and purification of Huperzine A from Huperzia serrata (Thunb) Trev. was studied in this paper. To get rid of some pigments and other impurities, some of chemical techniques for separation such as extraction with organic acid, absorption with charcol and re-crystallization with chloroform were employed. The results suggested that:
SHEN Sheng-rong, Yu Hai-ning, JIN Chao-fang, XU Yue-rong   +3 more
openaire   +3 more sources

Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease

Drug Delivery, 2020
Increasingly attention has been paid to the transdermal drug delivery systems with microneedles owing to their excellent compliance, high efficiency, and controllable drug release, therefore, become promising alternative with tremendous advantages for ...
Qinying Yan, Weiwei Wang, Jiaqi Weng, Zhenghan Zhang, Lina Yin, Qingliang Yang, F. Guo, Xingang Wang, Fan Chen, Gensheng Yang   +9 more
semanticscholar   +2 more sources

Huperzia serrata Extract ‘NSP01’ With Neuroprotective Effects-Potential Synergies of Huperzine A and Polyphenols

Frontiers in Pharmacology, 2021
Huperzia serrata (Thunb.) Trevis is widely used in traditional asiatic medicine to treat many central disorders including, schizophrenia, cognitive dysfunction, and dementia. The major alkaloid, Huperzine A (HA), of H. serrata is a well-known competitive
N. Callizot, M. Campanari, L. Rouvière, G. Jacquemot, A. Henriques, E. Garayev, P. Poindron   +6 more
semanticscholar   +3 more sources

Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]

Clin Case Rep
ABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK, Nyuydzefon B, Kouomogne BAN, Siysi VV.   +3 more
europepmc   +2 more sources

Alzheimer's Disease: The Current and Emerging Treatment Approaches. [PDF]

Behav Neurol
Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease characterized by amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs) as its main pathological features. It mainly manifests as cognitive dysfunction, and its pathological process may occur before symptom onset.
Pang R, Jia Q, Ma C, Li T, Bi W, Wang H, Liu R, Chen P, Lee ES, Jiang HB.   +9 more
europepmc   +2 more sources

De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. [PDF]

PLoS ONE, 2015
Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these ...
Guowei Zhang, Wenjuan Wang, Xiangmei Zhang, Qianqian Xia, Xinmei Zhao, Youngjoon Ahn, Nevin Ahmed, Andreea Cosoveanu, Mo Wang, Jialu Wang, Shaohua Shu   +10 more
doaj   +1 more source

Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes [PDF]

Alzheimers Dement
Abstract Importance Alzheimer's disease (AD), the most prevalent form of dementia, contributes significantly to global disability. Pharmacotherapies (PTs) often have adverse effects, while diverse non‐pharmacotherapies (NPTs) lack comprehensive comparative evaluations against PTs.
Boongird C, Tearneukit W, Wongpipathpong W, Suthutvoravut U, Thongpan M, Pongsettakul N, McKay G, Rattanasiri S, Anothaisintawee T, Thakkinstian A.   +9 more
europepmc   +2 more sources