Antioxidant, Anti-Inflammatory, and Chemical Composition Analysis of In Vitro <i>Huperzia serrata</i> Thallus and Wild <i>Huperzia serrata</i>. [PDF]
MoleculesHuperzine A is a preferred treatment option for Alzheimer’s disease. Huperzia serrata (Thunb. ex Murray) Trev. (H. serrata) has garnered significant attention for its ability to produce Huperzine A (HupA). However, natural populations of wild H. serrata (
Huang Y +7 more
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Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. [PDF]
PLoS ONE, 2015 Considerable studies indicate huperzine A is a promising natural product to suppress neuronal damages induced by β-amyloid (Aβ), a key pathogenic event in the Alzheimer's disease (AD).
Yun Lei +7 more
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Rapid Structural Analysis of Natural Products Using MicroED. [PDF]
SmallThe cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Lin J, Paz O, Unge J, Gonen T.
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Huperzine A for vascular dementia [PDF]
Cochrane Database of Systematic Reviews, 2008 Huperzine A, a form of herbal medicine, has been considered as an alternative treatment for vascular dementia (VaD) in China.To assess the efficacy and safety of Huperzine A in patients with vascular dementia.The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG) was searched on 7 July 2008 using the terms: huperzi ...
Zilong, Hao +3 more
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Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A. [PDF]
Appl Microbiol BiotechnolPlant-derived (−)-Huperzine A (HupA), the bioactive enantiomer of the acetylcholinesterase inhibitor used for Alzheimer’s disease (AD) therapy, is limited by the scarcity of Huperzia serrata (HS), while chemically synthesized (+)-HupA is clinically ...
Wen-Xia H +9 more
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Loss of Pathogenicity and Evidence of Horizontal Gene Transfer in Colletotrichum gloeosporioides From a Medicinal Plant. [PDF]
Mol Plant PatholA Colletotrichum gloeosporioides strain from Huperzia serrata lacks key pathogenicity genes CgDN3 and cap20 and has fewer pelB, pnl and pg genes. pksIII, for synthesis of huperzine A, was probably acquired by the host plant from the fungus. ABSTRACT Colletotrichum gloeosporioides is a major agricultural pathogen of crops that has also been identified ...
Yue X +17 more
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Huperzine A for mild cognitive impairment [PDF]
Cochrane Database of Systematic Reviews, 2010 Mild cognitive impairment (MCI) has been proposed as a condition of intermediate symptomatology between the cognitive changes of ageing and fully developed symptoms of dementia. Treatment in the stages of MCI may delay the deterioration of cognitive impairment and delay the progression to dementia. Currently, the treatments for Alzheimer's disease have
Jirong, Yue +5 more
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Current Plant Biology, 2020 Chinese toothed clubmoss (Huperzia serrata) is a primitive fern native in certain types of forests. It is severely endangered in China due to its difficult propagation and massive hunting for huperzine A to improve and prevent Alzheimer’s disease.
Qing-Zhong Peng +4 more
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Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study [PDF]
PeerJ, 2018 Objective This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells.
Xiao-na Hu +6 more
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Biosynthesis of plant neuroactive alkaloids treating Alzheimer's disease. [PDF]
Front PharmacolYin Q, Zhu Z, Yang M.
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