Results 41 to 50 of about 5,858 (232)

Tyrosine-based rivastigmine-loaded organogels in the treatmant of Alzheimer's disease [PDF]

, 2010
Faculté de PharmacieOrganogels can be prepared by immobilizing an organic phase into a threedimensional network coming from the self-assembly of a low molecular weight gelator molecule.
Bastiat, Guillaume, Dumont, Yvan, Fuhrmann, Gregor, Furtos, Alexandra, Leroux, Jean-Christophe, Motulsky, Aude, Plourde, François, Quirion, Rémi   +7 more
core   +4 more sources

The temporal and spatial endophytic fungal community of Huperzia serrata: diversity and relevance to huperzine A production by the host

BMC Microbiology, 2022
Background Plants maintain the steady-state balance of the mutually beneficial symbiosis relationship with their endophytic fungi through secondary metabolites.
Zhuhui Shen, Xubing Liu, Jia Yang, Yanli Wang, K. Yao, Qing-Qing Huo, Yanping Fu, Yahui Wei, B. Guo   +8 more
semanticscholar   +1 more source

Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system

Data in Brief, 2020
Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs greatly contributed
Tingting Peng, Yin Shi, Chune Zhu, Disang Feng, Xiangyu Ma, Peipei Yang, Xuequn Bai, Xin Pan, Chuan-yu Wu, Wen Tan, Chuanbin Wu   +10 more
doaj   +1 more source

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease

Current Issues in Molecular Biology, 2021
The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is an ...
Hafsa Amat-ur-Rasool, Mehboob Ahmed, Shahida Hasnain, Abrar Ahmed, Wayne Grant Carter   +4 more
doaj   +1 more source

Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews. [PDF]

, 2016
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative ...
Clemson, Lindy, Crotty, Maria, Dyer, Suzanne M, Laver, Kate, Whitehead, Craig Hamilton   +4 more
core   +1 more source

A Friendly Relationship between Endophytic Fungi and Medicinal Plants: A Systematic Review [PDF]

, 2016
Endophytic fungi or endophytes exist widely inside the healthy tissues of living plants, and are important components of plant micro-ecosystems. Over the long period of evolution, some co-existing endophytes and their host plants have established a ...
Abd_Allah, Ahmad, Amna, Bacon, Barazani, Bashyal, Behie, Bittleston, Bussaban, Camatti-Sartori, Cao, Cao, Carroll, Cavaglieri, Chakravarthi, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chithra, Chutima, Cui, D'Amico, Dai, Deng, Dingle, Duan, Eyberger, Faeth, Fan, Firáková, Gangadevi, Gangadevi, Gange, Gao, Gunatilaka, Guo, Guo, Guo, Gómez-Vidal, Harper, Hartley, Herrera-Carrillo, Huang, Huang, Jiang, Ju, Khan, Kim, Kour, Kozyrovska, Kumaran, Kumaran, Kusari, Kusari, Kusari, Kusari, Kusari, Kusari, Li, Li, Li, Li, Li, Li, Liu, Liu, Lu, Maciá-Vicente, Maehara, Meng, Ming, Mo, Moricca, Nascimento, Nejad, Osono, Pan, Puri, Puri, Qiu, Qiu, Redman, Rehman, Ren, Richardson, Rodrigues, Rodriguez, Rodriguez, Saikkonen, Saikkonen, Senthil Kumaran, Sherameti, Shrestha, Shwab, Shweta, Sieber, Silva, Song, Stierle, Stierle, Strobel, Strobel, Strobel, Sumarah, Sun, Sun, Suryanarayanan, Tan, Tang, Tofern, Torres, Unterseher, Venkatachalam, Wang, Wang, Wang, Wang, Wang, Wang, Waqas, Weyens, Wu, Yan, Yang, Yang, Yin, Yu, Zeng, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhou, Zhou   +141 more
core   +1 more source

Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts [PDF]

, 2013
Objective: the aim of this study is to investigate the in vitro antioxidant activity, the total phenol and flavonoid content and the possible protective effects of commercial propolis on gentamicin-induced nephrotoxicity in rabbits.
Brun, Reto, Erdogan Orhan, Ilkay, Erdogan Orhan, Ilkay, Kaiser, Marcel, Sener, Bilge, Tasdemir, Deniz   +5 more
core   +1 more source

Mechanistic Insight into the Binding of Huperzine a with Human Transferrin: Computational, Spectroscopic and Calorimetric Approaches

ACS Omega, 2022
Huperzine A (HupA), an alkaloid found in the club moss Huperzia Serrata, has been in use for centuries in Chinese traditional medicine to treat dementia owing to its ability to inhibit the cholinergic enzyme acetylcholinesterase (AChE), thus acting as an
A. Atiya, F. Alhumaydhi, Anas Shamsi, A. Olatunde, S. Alsagaby, Waleed Al Abdulmonem, S. Sharaf, M. Shahwan   +7 more
semanticscholar   +1 more source

Study of the interaction of Huperzia saururus Lycopodium alkaloids with the Acetylcholinesterase enzyme [PDF]

, 2013
In the present study, we describe and compare the binding modes of three Lycopodium alkaloids (sauroine, 6-hydroxylycopodine and sauroxine; isolated from Huperzia saururus) and huperzine A with the enzyme acetylcholinesterase. Refinement and rescoring of
Agnese, Mariel, Borioni, José Luis, Cabrera, Jose Luis, Ortega, María Gabriela, Pierini, Adriana Beatriz, Puiatti, Marcelo, Vallejo, Mariana Guadalupe   +6 more
core   +1 more source

Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides and Their Acetylcholinesterase Inhibitory Activity

Molecules, 2014
Four new lycodine-type alkaloids, namely 16-hydroxyhuperzine B (1), N-methyl-11-acetoxyhuperzine B (2), 8,15-dihydrolycoparin A (3) and (7S,12S,13R)-huperzine D-16-O-β-d-glucopyranoside (4), along with ten known analogues 5−14, were isolated from the ...
Dong-Bo Zhang, Jian-Jun Chen, Qiu-Yan Song, Li Zhang, Kun Gao   +4 more
doaj   +1 more source