Results 51 to 60 of about 5,858 (232)

A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2

Heliyon, 2020
The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus.
Yanqiong Chen, Huan Tao, Silan Shen, Zhiyong Miao, Lili Li, Yongqian Jia, Hu Zhang, Xiufeng Bai, Xinyuan Fu   +8 more
doaj   +1 more source

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

Free energy landscape for the binding process of Huperzine A to acetylcholinesterase [PDF]

, 2012
Drug-target residence time (t = 1/koff, where koff is the dissociation rate constant) has become an important index in discovering betteror best-in-class drugs.
Fang Bai, Held, Honglin Li, Hualiang Jiang, Jianpeng Ma, Jing Chen, José N. Onuchic, Junfeng Gu, Mobley, Petřek, Qiufeng Liu, Swinney, Xicheng Wang, Xu, Yan, Yechun Xu   +15 more
core   +1 more source

Endophytic Fungal Community of Huperzia serrata: Diversity and Relevance to the Production of Huperzine A by the Plant Host

Molecules, 2021
As the population ages globally, there seem to be more people with Alzheimer’s disease. Unfortunately, there is currently no specific treatment for the disease. At present, Huperzine A (HupA) is one of the best drugs used for the treatment of Alzheimer’s
Lingli Cui, Hamza Armghan Noushahi, Yipeng Zhang, Jinxin Liu, A. Coșoveanu, Ying Liu, Ling Yan, Jing Zhang, Shaohua Shu   +8 more
semanticscholar   +1 more source

Prediction of anti-Alzheimer’s activity of flavonoids targeting acetylcholinesterase in silico [PDF]

, 2017
Introduction – Prenylated and pyrano-flavonoids of the genus Artocarpus J. R. Forster & G. Forster are well known for their acetylcholinesterase (AchE) inhibitory, anticholinergic, antiinflammatory, antimicrobial, antioxidant, antiproliferative and ...
Abdullah, SA, Basar, N, Choudhury, MD, Choudhury, PR, Das, S, Jamil, S, Laskar, MA, Lathiff, SMA, Mitra, A, Nahar, L, Sarker, SD, Talukdar, AD   +11 more
core   +1 more source

Huperzine A in SCI [PDF]

Science-Business eXchange, 2013
Harvard Medical School researchers have shown that the plant-derived small molecule huperzine A can reduce neuropathic pain in rats with spinal cord injury. Insero Health has licensed IP covering epilepsy and neuropathic pain and plans to report Phase Ib data this year in treatment-resistant epilepsy.
openaire   +1 more source

Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Molecules, 2014
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa.
Nguyen Ngoc Chuong, Nguyen Thi Thu Huong, Tran Manh Hung, Tran Cong Luan   +3 more
doaj   +1 more source

Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases

Molecules, 2021
Alkaloids are a class of secondary metabolites that can be derived from plants, fungi and marine sponges. They are widely known as a continuous source of medicine for the management of chronic disease including cancer, diabetes and neurodegenerative ...
Yew Rong Kong, Kai Ching Tay, Yi Xiang Su, Choon Kwang Wong, Wen Nee Tan, Kooi Yeong Khaw   +5 more
doaj   +1 more source

A network model to investigate structural and electrical properties of proteins

, 2007
One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest.
Alfinito E, Atilgan A R, Cecilia Pennetta, Debye P, Edérlyi A, Eleonora Alfinito, Fisher Weiss T, Kim M K, Lino Reggiani, McCammon A, Menon S T, Pennetta C, Pennetta C, Schlag E W, Taketomi H, Warshel A   +15 more
core   +1 more source

Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases [PDF]

, 2015
The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases.
Acquatella-Tran Van Ba, I., Béringue, V., Chatonnet, A., Goffic, R. Le, Grznarova, K., Herzog, Laetitia, Muñoz-Torrero López-Ibarra, Diego, Nachon, Florian, Rezaei, H., Torrent, Joan, Trovaslet, M., Vílchez Acosta, Alba del Valle   +11 more
core   +4 more sources