Results 61 to 70 of about 5,858 (232)

Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury [PDF]

, 2020
The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction.
Bagiella, Emilia, Christoforou, Andrea, Giacino, Joseph T., Hammond, Flora M., Long, David, Maurer-Karattup, Petra, Sherer, Mark   +6 more
core   +1 more source

Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

Journal of Neurochemistry, 2021
Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are devastating diseases in the elderly world, which are closely associated with progressive neuronal loss induced by a variety of genetic and/or environmental factors ...
Shinghung Mak, Wenming Li, H. Fu, Jialie Luo, W. Cui, Sheng-quan Hu, Y. Pang, P. Carlier, K. Tsim, R. Pi, Yifan Han   +10 more
semanticscholar   +1 more source

Huperzine A

Drugs in R & D, 2004
Huperzine A, an alkaloid isolated from Huperzia serrata, is a putative nootropic agent developed by the Chinese Academy of Sciences. Huperzine A is currently in phase III trials in China for the treatment of patients with Alzheimer's disease. The mechanism of action of huperzine A is suggested to be facilitated through the slow reversible inhibition of
openaire   +2 more sources

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine [PDF]

, 2016
published_or_final_versio
Chan, SW, Cui, G, Hoi, MPM, Kwan, YW, Lee, SMY, Leung, GPH, Tseng, HHL, Zhou, X   +7 more
core   +1 more source

In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Measurement Science Review, 2023
The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/1H MRS
Tvrdík Tomáš, Melicherčík Ľubomír, Šebeková Katarína, Szabó Jakub, Maková Marianna, Gogola Daniel, Kašparová Svatava   +6 more
doaj   +1 more source

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +2 more sources

In Silico-Guided Rational Drug Design and Semi-synthesis of C(2)-Functionalized Huperzine A Derivatives as Acetylcholinesterase Inhibitors

ACS Omega, 2021
Huperzine A (1, Hup A), a lycodine-type Lycopodium alkaloid isolated from Thai clubmosses Huperzia squarrosa (G. Forst.) Trevis., H. carinata (Desv. ex. Poir.) Trevis., H.
Shisanupong Anukanon, Pornkanok Pongpamorn, Wareepat Tiyabhorn, Jaruwan Chatwichien, Worawat Niwetmarin, R. Sessions, S. Ruchirawat, N. Thasana   +7 more
semanticscholar   +1 more source

Pharmacological treatments for vascular dementia: a systematic review and Bayesian network meta-analysis. [PDF]

Front Pharmacol
BackgroundVascular dementia (VaD) is one of the most prevalent, burdensome, and costly forms of dementia. Pharmacological treatment is often the first-line choice for clinicians; however, there is a paucity of comparative information regarding the ...
Dang C, Wang Q, Zhuang Y, Li Q, Feng L, Xiong Y, Lu Y.   +6 more
europepmc   +2 more sources

Neuronutraceuticals for Alzheimer's Disease Treatment: A Systematic Review of Randomised Controlled Trials Over the Last 20 Years

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
This PROSPERO‐registered review analysed 37 RCTs on neuronutraceuticals for Alzheimer's disease. Despite diverse targets—amyloid/tau, inflammation, oxidative stress, metabolism, synaptic plasticity, cholinergic and hormonal—the evidence was of low quality. RoB2 flagged attrition (86.5%) and reporting bias (81%). Current data do not support clinical use;
Mehmet Akif Topcuoglu, Esen Saka
wiley   +1 more source

Rapid HPLC-ESI-MS/MS Analysis of Neurotransmitters in the Brain Tissue of Alzheimer’s Disease Rats before and after Oral Administration of Xanthoceras sorbifolia Bunge

Molecules, 2018
In order to explore the potential therapeutic effect of Xanthoceras sorbifolia Bunge. against Alzheimer’s disease, an HPLC-MS/MS method has been developed and validated for simultaneous determination in rat brain of eight neurotransmitters ...
Zheng Sun, Qing Li, Kaishun Bi
doaj   +1 more source