Results 21 to 30 of about 272 (88)
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.“Three fruit (LG, SH, and WH) and one leaves (LGLV) genotypes of snake melon were chemically profiled by LC‐HRMS. LGLV was chemically distinct and was active against MRSA as evidenced by an in vivo model. Moreover, LGLV counteracted H2O2‐induced cell senescence.
Mohammed N. A. Khalil +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Pharmacological inhibition of glutaminase with drug CB‐839 restores mitochondrial function in senescent myoblasts and enhances muscle strength and endurance in progeria mice. ABSTRACT Age‐associated loss of skeletal muscle mass and function, also known as sarcopenia, is closely linked to mitochondrial dysfunction.
Hamsa Vardini Senthil Kumar +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Progerin accumulation downregulates the expression of m6A methyltransferases METTL3 and METTL14 in cardiac tissues, impairing m6A modification‐mediated regulation of target genes including Casq2, Ifna and Ifnb, leading to calcium signaling dysregulation and pro‐inflammatory activation in the aged heart.
Shixiao Wang +17 more
wiley +1 more source
Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome
Przegląd Dermatologiczny, 2020 Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births.
Iti Varshney +5 more
doaj +1 more source
A 3-year-old girl with old face appearance: Case report
Journal of Dermatology and Dermatologic Surgery, 2022 Hutchinson–Gilford Progeria Syndrome (HGPS) is a genetic disorder. Patients who suffer from this disorder show premature aging and a “plucked-bird” appearance on the face. This case reports a 3-year-old female, who manifested the symptoms of HGPS.
Hamad A Alfahaad
doaj +1 more source
MTR4: A Conserved Youth Factor for Vascular Endothelium
Aging Cell, Volume 25, Issue 10, October 2026.Senescence‐induced SYVN1 degrades MTR4 via K638 ubiquitination. MTR4 loss disrupts its binding to BUB3 and destabilizes BUB3, diminishing BUBR1 and driving endothelial senescence. MTR4 restoration reverses vascular aging in mice and extends C. elegans lifespan.
Zhenyuan Guo +7 more
wiley +1 more source
Hutchinson - Gilford progeria syndrome: A rare case report
Indian Dermatology Online Journal, 2014 Hutchinson - Gilford Progeria Syndrome is a rare genetic disorder characterized by premature aging involving the skin, bones, heart, and blood vessels. We report a three-year-old boy with clinical manifestations characteristic of this syndrome.
Subhash Kashyap +2 more
doaj +1 more source
Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case
Вопросы современной педиатрии, 2022 Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions.
Natalia V. Buchinskaya +3 more
doaj +1 more source
The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis
Biology of the Cell, Volume 118, Issue 10, October 2026.We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Sandrine Fraboulet +2 more
wiley +1 more source
Simultaneous Shoulder and Hip Dislocation in a 12-Year-Old Girl with Hutchinson-Gilford Progeria Syndrome [PDF]
Acta Medica Iranica, 2012 Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature ageing disorder that is characterized by accelerated degenerative changes of the cutaneous, musculoskeletal and cardiovascular systems.
Ramin Espandar +2 more
doaj +1 more source