Results 41 to 50 of about 1,306,732 (153)

Anesthetic management of a child with Hutchinson–Gilford progeria syndrome [PDF]

Journal of Anaesthesiology Clinical Pharmacology
Sunil Rajan, Priyanka Joseph, Gayathri Sreekumar, Maharnab Bhuyan   +3 more
doaj   +2 more sources

The decision‐making process and criteria in selecting candidate drugs for progeria clinical trials

EMBO Molecular Medicine, 2016
Hutchinson–Gilford progeria syndrome (progeria) is an extremely rare premature aging disease with a population prevalence of 1 in 20 million. Nevertheless, propelled by the discovery of a causal mutation in the lamin A/C gene (LMNA) (De Sandre‐Giovannoli
Leslie B Gordon, Mark W Kieran, Monica E Kleinman, Tom Misteli   +3 more
doaj   +1 more source

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Nature Communications, 2019
Hutchinson–Gilford progeria syndrome causes premature aging. Here the authors show that activation of the DNA damage response at dysfunctional telomeres and transcription of telomeric non-coding RNAs contributes to the pathogenesis, which can be ...
Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson, Fabrizio d’Adda di Fagagna   +12 more
doaj   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells [PDF]

, 2014
To study the vulnerability of smooth muscle cells (SMCs) in Hutchinson-Gilford Progeria Syndrome (HGPS)
Rocha, I., Ferreira, Lino, Nissan, Xavier, Vazão, Helena, Pitrez, Patricia R.   +4 more
core   +2 more sources

Progeria in siblings: A rare case report

Indian Journal of Dermatology, 2011
Progeria, also known as Hutchinson-Gilford syndrome, is an extremely rare, severe genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. It is an autosomal dominant disorder.
R Sowmiya, D Prabhavathy, S Jayakumar
doaj   +1 more source

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development. [PDF]

PLoS ONE, 2011
Today, there are at least a dozen different genetic disorders caused by mutations within the LMNA gene, and collectively, they are named laminopathies.
Sofía Rodríguez, Maria Eriksson
doaj   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, Volume 293, Issue 21, Page 6444-6466, November 2026.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Estudio del envejecimiento con un modelo celular del síndrome de progeria de Hutchinson-Gilford

, 2020
Se presentan en forma resumida los principaleshallazgos del trabajo de Liu y col. (1), investigadores delInstituto Salk, California, publicado en abril de 2011, dondese describe un modelo celular in vitro del síndrome deprogeria de Hutchinson ...
de Montbrun, Dra. Lilia Cruz
core   +1 more source

A BRIEF REVIEW ON HUTCHINSON-GILFORD PROGERIA SYNDROME

, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) was first documented in 1886 in the medical literature. A HGPS patient has the physical characteristics and appearances of an elderly individual.
Savitha mol.G.M, Anaswara.S.P, Kiran.K.J, Sam Jeeva Kumar, William Arputha Sundar
core   +1 more source