Results 61 to 70 of about 7,479 (177)

Age-dependent changes of nuclear morphology are uncoupled from longevity in Caenorhabditis elegans IGF/insulin receptor daf-2 mutants [PDF]

, 2016
Nuclear envelope (NE) architecture and aging have been associated since the discovery that certain human progeria diseases are due to perturbations in processing of lamin A protein, generating alterations in NE morphology. However, whether changes in the
Askjaer, Peter, Muñoz, Manuel J., Pérez-Jiménez, Mercedes M., Rodríguez-Palero, María Jesús, Ródenas, Eduardo   +4 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, Volume 600, Issue 4, Page 392-417, February 2026.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm

Cell & Bioscience, 2022
Background Mesenchymal stem cells (MSCs) are emerging as the mainstay of regenerative medicine because of their ability to differentiate into multiple cell lineages.
Wei Jin, Yi He, Tuo Li, Fei Long, Xin Qin, Yuan Yuan, Ge Gao, Hosen Md Shakhawat, Xinguang Liu, Guoxiang Jin, Zhongjun Zhou   +10 more
doaj   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Hutchinson-Gilford Progeria Syndrome

Online Journal of Health & Allied Sciences, 2014
Hutchinson-Gilford Progeria syndrome (HGPS) is a rare pediatric genetic syndrome associated with a characteristic aged appearance very early in life, generally leading to death in the second decade of life.
Gopal G, Belavadi GB
doaj  

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole Guerrera, Alexandria Regan, Liqin Lin, Erica Schwarz, Aurelien Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam B. Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, Min‐Jong Kang, Danielle R. Bruns, Patty J. Lee, George Tellides, Jay D. Humphrey, Naftali Kaminski, Abhay B. Ramachandra, Edward P. Manning   +22 more
wiley   +1 more source

Síndrome de progeria de Hutchinson Gilford: mutación silenciosa gly608gly en el gen lmna: reporte de caso y revisión

Iatreia, 2010
INTRODUCCIÓN : mutaciones en el gen LMNA, LAMINA A/C; originan un grupo de desordenes genéticos que pueden ser clasificados en cuatro grupos: enfermedades de músculo estriado y cardiaco, síndromes lipodistroficos, neuropatías periféricas y progeria (1 ...
Lucero Tarin A., Andrea Fiaga, Ximena Saenz   +2 more
doaj  

Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy [PDF]

, 2016
published_or_final_versio
Jiang, Y, Lai, KWH, Lau, VYM, Lee, YK, Ng, KM, RAN, X, Siu, DCW, Tse, HF   +7 more
core   +1 more source

Genetic Landscape of Robin Sequence: A Systematic Review

Clinical Genetics, Volume 109, Issue 2, Page 218-232, February 2026.
This systematic review summarizes the genetic landscape of Robin sequence (RS), highlighting key differences between isolated and non‐isolated forms and emphasizing the role of up‐to‐date genetic testing for diagnosis and clinical management. ABSTRACT Robin sequence (RS) is a congenital condition characterized by micrognathia, glossoptosis, and upper ...
Shirley van de Velde, Aebele B. Mink van der Molen, Augusta M. A. Lachmeijer, Daan de Leijer, Jeroen J. Smits, Maarten P. G. Massink, Sarah L. Versnel, Marie‐José H. van den Boogaard, Emma C. Paes   +8 more
wiley   +1 more source

A Case Report of Hutchinson-Gilford Progeria Syndrome

The Journal of Qazvin University of Medical Sciences, 2019
Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic condition occurs one in every 8 million live births. HGPS is characterized by premature aging in various organs.
Siamak Yaghoubi, Sareh Mohammadi, Leili Yekefallah, Alireza Taromiha, Ameneh Bagheri   +4 more
doaj   +1 more source