Results 51 to 60 of about 1,306,732 (153)

Anesthetic considerations in children with Hutchinson-Gilford progeria syndrome: A narrative review

open access: yes, 2020
BACKGROUND: Hutchinson-Gilford progeria syndrome is a rare disease in childhood that results in premature aging. The presence of multisystem derangements including skin, bone, and joint diseases and possibly a difficult airway makes the anesthetic ...
Hoogma, Danny   +5 more
core   +1 more source

Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients [PDF]

open access: yes, 2018
Comment on: “Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies” by Steve Horvath, et al. published in Aging Volume 10, Issue 7, pp 1758—75.
Teschendorff, AE
core   +1 more source

Mutations Involved in Premature-Ageing Syndromes

open access: yesThe Application of Clinical Genetics, 2021
Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, ItalyCorrespondence: Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies ...
Coppedè F
doaj  

Molecular elucidations of hutchinson-gilford progeria syndrome: A hope for managing horrors of premature aging in children

open access: yesPakistan Journal of Pharmaceutical Sciences, 2020
Hutchinson-Gilford progeria syndrome (or Progeria) is an exceptionally rare genetic disorder in children. It is caused by a rare point mutation in the lamin gene. It encodes lamin A protein, resulting in the de-shaping of nuclear membrane.
Bilal Ahmed   +5 more
doaj   +1 more source

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization

open access: yesThe FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde   +2 more
wiley   +1 more source

Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm

open access: yesCell & Bioscience, 2022
Background Mesenchymal stem cells (MSCs) are emerging as the mainstay of regenerative medicine because of their ability to differentiate into multiple cell lineages.
Wei Jin   +10 more
doaj   +1 more source

Induced Pluripotent Stem Cell‐Derived Small‐Diameter Vascular Grafts: Scaffold Design, Immune Engineering, and Clinical Translation

open access: yesJournal of Cellular Physiology, Volume 241, Issue 9, September 2026.
ABSTRACT Small‐diameter vascular grafts (≤ 6 mm) remain a critical unmet need in cardiovascular surgery, as autologous vessels are unavailable in up to 30% of patients requiring coronary or peripheral bypass. Induced pluripotent stem cells (iPSCs) have emerged as a transformative cell source for tissue‐engineered vascular grafts (TEVGs), offering ...
Dohee Kim, Seohyun Choo, Seunghun S. Lee
wiley   +1 more source

LivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
We present LivAge, an online aging clock that estimates murine transcriptomic age from hepatic RNA‐seq data. Externally validated, it detects accelerated aging in progeroid models and quantifies the effect of geroprotective interventions, providing an accurate, accessible, and ready‐to‐use tool for aging research.
Víctor Celemín‐Capaldi   +6 more
wiley   +1 more source

Síndrome de progeria de Hutchinson Gilford: mutación silenciosa gly608gly en el gen lmna: reporte de caso y revisión

open access: yesIatreia, 2010
INTRODUCCIÓN : mutaciones en el gen LMNA, LAMINA A/C; originan un grupo de desordenes genéticos que pueden ser clasificados en cuatro grupos: enfermedades de músculo estriado y cardiaco, síndromes lipodistroficos, neuropatías periféricas y progeria (1 ...
Lucero Tarin A.   +2 more
doaj  

Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians. Supplementation of AKK extends healthspan and alleviates age‐related decline through direct host–microbe interactions and its bioactive derivatives, which collectively enhance gut barrier integrity, restore metabolic homeostasis ...
Ting Zhang   +7 more
wiley   +1 more source

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