Hutchinson-gilford progeria syndrome

Mechanisms of Ageing and Development, 2009
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous research has shown that the average telomere length in fibroblasts from HGPS patients is shorter than in age-matched controls. How mutations in lamin A lead to shortened telomere
Michelle L, Decker +3 more
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Hutchinson–Gilford progeria syndrome

Clinical Genetics, 2004
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that causes premature, rapid aging shortly after birth. Recently, de novo point mutations in the Lmna gene have been found in individuals with HGPS. Lmna encodes lamin A and C, the A‐type lamins, which are an important structural component of the nuclear envelope.
R L, Pollex, R A, Hegele
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Lethal neonatal Hutchinson‐Gilford progeria syndrome

American Journal of Medical Genetics, 1999
We report on a 35-week gestation female fetus with Hutchinson-Gilford progeria (HGP). This patient, who is the first reported with neonatal HGP in the English literature but is the fourth, counting three previous French cases, supports the existence of a more severe prenatal form of progeria. She died 7 hours after birth and presented with intrauterine
J I, Rodríguez +3 more
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progeria
3. good health
humans

premature aging
female
male

child, preschool
child
medicine