Results 81 to 90 of about 7,521 (211)

Hutchinson-Gilford Progeria Syndrome (HGPS)

Journal of Oral Diagnosis, 2016
Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic condition characterized by premature aging and it’s about one case for every four to eight million people. Children affected usually have premature death due to cardiovascular problems.
Alexandre Simoes Nogueira, Carlos Bruno Pinheiro Nogueira, Rômulo Medeiros, Ana Cristina Beviláqua, Paulo Sérgio da Silva Santos, Izabel Regina Fischer Rubira-Bullen, Eduardo Sanches Gonçales   +6 more
openaire   +1 more source

Craniofacial Abnormalities in Hutchinson-Gilford Progeria Syndrome [PDF]

American Journal of Neuroradiology, 2012
HGPS is a rare syndrome of segmental premature aging. Our goal was to expand the scope of structural bone and soft-tissue craniofacial abnormalities in HGPS through CT or MR imaging. Using The Progeria Research Foundation Medical and Research Database, 98 imaging studies on 25 patients, birth to 14.1 years of age, were comprehensively reviewed.
N J, Ullrich, V M, Silvera, S E, Campbell, L B, Gordon   +3 more
openaire   +2 more sources

Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy‐Induced Senescent Cells

Aging Cell, Volume 25, Issue 1, January 2026.
In the course of TIS, cells undergo a profound epigenomic reorganization that underlies the development of a senescence‐associated phenotype and formation of an inflammatory microenvironment. ABSTRACT Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling.
Ge Zhang, Wei Zhang, Changxu Wang, Zhirui Jiang, Qixia Xu, Haipeng Li, James L. Kirkland, Gang Wei, Yu Sun   +8 more
wiley   +1 more source

The fat‐heart entanglement and the role of ‘osteopontin mechanics’ in cardiometabolic senescence

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Abstract Background Residual cardiovascular (CV) risk persists despite therapeutic advances. Obesity is heterogeneous, and visceral adipose tissue (VAT) dysfunction (‘adiposopathy’) complicates risk stratification. Osteopontin (OPN) is a pleiotropic mediator implicated in VAT inflammation, senescence‐associated pathways, atherosclerosis and myocardial ...
Cristina Michelauz, Fabrizio Montecucco, Luca Liberale, Federico Carbone   +3 more
wiley   +1 more source

The epidemiology of premature aging and associated comorbidities

Clinical Interventions in Aging, 2013
Fabio Coppedè Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Hutchinson–Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood ...
Coppedè F
doaj  

Mouse models of ageing and their relevance to disease [PDF]

, 2016
Ageing is a process that gradually increases the organism’s vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex.
Dogan, Soner, Gonzalez-Navarro, Herminia, Koks, Sulev, Potter, Paul, Tuna, Bilge Guvenc, Vandenbroucke, Roosmarijn E   +5 more
core   +2 more sources

French‐Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Gene Panel Analysis Through Genotyping or Sequencing in Pharmacogenetics

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background The implementation of pharmacogenetics in clinical practice increasingly relies on multigene panels. Objectives The objective of this study is to develop harmonized recommendations for the design and analytical implementation of multigene pharmacogenetic panels, defining clinically relevant genes and associated regions of interest ...
Nicolas Picard, Estelle Ayme‐Dietrich, Sylvie Quaranta, Tiphaine Adam‐De‐Beaumais, Abd El Kader Ait Tayeb, Hugo Alarcan, Dorra Amor, David Barthelemy, Mouna Ben Sassi, Séverine Cunat, Mouna Daldoul, Hervé Delacour, Marie‐Christine Etienne‐Grimaldi, Xavier Fonrose, Benjamin Hennart, Louis Lebreton, Stephanie Malard, Céline Narjoz, Asma Omezzine, Nicolas Pallet, Léa Payen, Jeanne Petit, Fabienne Thomas, Sameh Trabelsi, Camille Tron, Céline Verstuyft, Paul Vilquin, Jean‐Christophe Boyer, Vincent Haufroid, French‐Speaking Network of Pharmacogenetics (RNPGx)   +29 more
wiley   +1 more source

Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

Clinical Interventions in Aging, 2008
Shian-ling Ding1, Chen-Yang Shen2,3,41Department of Nursing, Kang-Ning Junior College of Medical Care and Management, Taipei, Taiwan; 2Institute of Biomedical Sciences, and 3Life Science Library, Academia Sinica, Taipei, Taiwan; 4Graduate Institute of ...
Shian-ling Ding, Chen-Yang Shen
doaj  

Research Models for Studying Vascular Calcification [PDF]

, 2020
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen, Giet, Markus van der, Herrmann, Jaqueline, Schuchardt, Mirjam, Tölle, Markus   +4 more
core   +1 more source

The Hutchinson-Gilford progeria syndrome

The Journal of Pediatrics, 1972
The Journal of Pediatrics 80 (1972) 697-724.
Department of Pediatrics, University of Florida College of Medicine, Gainesville, Fla. USA ( host institution ), DeBusk, Franklin L.   +1 more
openaire   +2 more sources