Results 101 to 110 of about 1,306,775 (184)

Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments

, 2018
The Hutchinson-Gilford Progeria syndrome is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting skin, musculoskeletal system and blood vessels, also other features supporting ...
Sutiono, D. R. (Dias), Adeline, F. (Fransiska)   +1 more
core  

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome. [PDF]

Aging Cell, 2023
Ferreira-Marques M, Carvalho A, Franco AC, Leal A, Botelho M, Carmo-Silva S, Águas R, Cortes L, Lucas V, Real AC, López-Otín C, Nissan X, de Almeida LP, Cavadas C, Aveleira CA.   +14 more
europepmc   +1 more source

Progerin cross-linking stiffens the nucleus and impairs mechanosensation in Hutchinson-Gilford progeria syndrome. [PDF]

J Cell Sci
Srivastava LK, Ghagre A, Duchastel-Vassaramva I, Ehrlicher AJ.   +3 more
europepmc   +1 more source

Developing and Applying a Yeast Model of Hutchinson-Gilford Progeria Syndrome

The human premature aging disorder Hutchinson-Gilford progeria syndrome can, by virtue of its single molecular cause, be introduced to other living systems which allows for a more controlled and nuanced study of the disease.
Chivers, Christopher Patrick
core  

Lonafarnib clinical trials demonstrate uncoupling of the muscle-bone unit in Hutchinson-Gilford Progeria Syndrome. [PDF]

J Bone Miner Res
Kreienkamp RJ, Gordon LB, Ehrbar R, Pendleton A, Schiferl DJ, Lyass A, Kleinman ME, Snyder BD, Gordon CM.   +8 more
europepmc   +1 more source

Correction: Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress. [PDF]

Front Physiol
Kennedy CC, Carter JL, Truskey GA.
europepmc   +1 more source

Stem cell–associated osteogenic deficiency causes craniofacial deformities with progeroid accumulation of prelamin A

JCI Insight
Mutations in LMNA, encoding nuclear lamina protein Lamin A/C, cause premature aging disorders, most notably Hutchinson-Gilford progeria syndrome. Despite obvious skull abnormalities in patients with progeria, the etiology remains elusive.
Kai Li, Trunee Hsu, Hitoshi Uchida, Tingxi Wu, Susan Michaelis, Howard Worman, Wei Hsu   +6 more
doaj   +1 more source

Epidural hematoma in a pediatric patient with Hutchinson-Gilford progeria syndrome: management considerations: a case report. [PDF]

Chin Neurosurg J
Ozmarasali AI, Sivas ZZ, Uguz I, Oto A.
europepmc   +1 more source

HMGA1-HP1β axis regulates premature aging in Hutchinson-Gilford progeria syndrome through chromatin remodeling. [PDF]

Nat Commun
Hu Q, Sun Q, Xiang W, Zhou Z, Sun H, Hu Y, Yang L, Wang C, Zhang F, Cong Y, Zhang Y, Xiao Y, Cong X.   +12 more
europepmc   +1 more source

Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids. [PDF]

Nat Commun
Kim DW, Kwon EJ, Jeon BJ, Kwon DH, Jang G, Yoon Y, Hwang Y, Lee H, Cha HJ.   +8 more
europepmc   +1 more source