Results 141 to 150 of about 1,306,775 (184)

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome. [PDF]

Nat Cell Biol
Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC.   +4 more
europepmc   +1 more source

The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway. [PDF]

Geroscience
Monterrubio-Ledezma F, Salcido-Gómez A, Zavaleta-Vásquez T, Navarro-García F, Cisneros B, Massieu L.   +5 more
europepmc   +1 more source

Long lifetime and tissue-specific accumulation of lamin A/C in Hutchinson-Gilford progeria syndrome. [PDF]

J Cell Biol
Hasper J, Welle K, Swovick K, Hryhorenko J, Ghaemmaghami S, Buchwalter A.   +5 more
europepmc   +1 more source

The Use of Peripheral Nerve Block and Intra-articular Steroid Injection for Pain Management in an Adolescent with Hutchinson-Gilford Progeria Syndrome: A Case Report. [PDF]

Acta Med Philipp
Endencia MCS, Sy Su KMC, Reyes CRB.
europepmc   +1 more source

Aging of Hutchinson–Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]

Experimental Gerontology, 2004
Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Joanna M Bridger, Ian R Kill
exaly   +7 more sources

Anesthetic considerations in children with Hutchinson-Gilford progeria syndrome: A narrative review

Paediatric Anaesthesia, 2020
BACKGROUND: Hutchinson-Gilford progeria syndrome is a rare disease in childhood that results in premature aging. The presence of multisystem derangements including skin, bone, and joint diseases and possibly a difficult airway makes the anesthetic ...
Kristof Nijs, Marc van de Velde
exaly   +2 more sources

Mechanisms of Premature Vascular Aging in Children With Hutchinson-Gilford Progeria Syndrome

Hypertension, 2012
Hutchinson-Gilford progeria syndrome is a rare, segmental premature aging syndrome of accelerated atherosclerosis and early death from myocardial infarction or stroke.
Armin Schwartzman, Leslie B Gordon, Nicole Wake   +2 more
exaly   +2 more sources

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Hutchinson–Gilford progeria syndrome

Clinical Genetics, 2004
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that causes premature, rapid aging shortly after birth. Recently, de novo point mutations in the Lmna gene have been found in individuals with HGPS. Lmna encodes lamin A and C, the A‐type lamins, which are an important structural component of the nuclear envelope.
R L, Pollex, R A, Hegele
openaire   +3 more sources

Telomere length in Hutchinson-Gilford Progeria Syndrome

Mechanisms of Ageing and Development, 2009
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous research has shown that the average telomere length in fibroblasts from HGPS patients is shorter than in age-matched controls. How mutations in lamin A lead to shortened telomere
Peter Lansdorp
exaly   +3 more sources