Results 101 to 110 of about 56,873 (208)

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Multi‐Omics Analyses Elucidate the Venom Components of the Wasp Vespa mandarinia

Ecology and Evolution, Volume 16, Issue 6, June 2026.
The wasp Vespa mandarinia was widely reared in Yunnan province. The venom was responsible for their aggressive behavior. Tweety proteases, hyaluronidase, venom dipeptidyl peptidase 4, and phospholipase A1 and A2 isozyme were identified. In addition, organic heterocyclic compounds, organic acids, and derivatives were found.
Yuan‐Chong Shi, Hai‐Feng Mo, Shu‐Hui Yu, Xiao‐Yun Niu, Pu Yang   +4 more
wiley   +1 more source

Ceragenin‐Loaded Tri‐Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing

Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.
ABSTRACT Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preventing infection remains a critical need in burn wound management. In this study, a novel ceragenin (CSA‐44)
Nawal Aljayyousi, Emel Tamahkar Irmak, Esra Karaca, Elif Tümay Özer, Oğuzhan Akgün, Ferda Arı, Aycan Yiğit Çınar, Çağla Bozkurt Güzel, Paul B. Savage, Bilgen Osman   +9 more
wiley   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Organ Medicine, Volume 3, Issue 2, Page 76-86, June 2026.
Cancer‐associated fibroblasts (CAFs) are key regulators of the pancreatic tumor microenvironment. Through metabolic reprogramming, CAFs support tumor growth by providing nutrients and remodeling extracellular matrix. CAF heterogeneity, including myCAF, iCAF, and apCAF subsets, contributes to immune modulation and therapeutic resistance.
Ziyi Qin, Jinyang Ma, Rui Ju, Lei Guo
wiley   +1 more source

Loss of Brain‐Derived Estrogen Is Associated With Sex‐ and Age‐Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression

Aging Cell, Volume 25, Issue 6, June 2026.
Age, sex, and estrogen loss are widely recognized risk factors for Alzheimer's disease. Here, we show that brain‐specific aromatase knockout (bArKO) and the resulting estrogen loss lead to memory impairment, reduced social interaction, and extracellular environment dysregulation selectively in aged female mice, but not in young female or male mice ...
Natalie C. Piehl, Ariel W. Halle, Guadalupe Rodriguez, Andrea Locci, Stacy Kujawa, Caroline Haywood, John Coon V, Ross P. McNally, Zaina A. Karim, Tianming You, Hongxin Dong, Serdar E. Bulun, Hong Zhao   +12 more
wiley   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source

High molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis

, 2011
Arnold J WeilNon-Surgical Orthopedics PC, Marietta, GA, USABackground: There is insufficient evidence to determine whether intra-articular injections may be effective for treatment of glenohumeral osteoarthritis.
Weil AJ
core  

Perinatal White Matter Injury: Connecting Histology, Pathophysiology and Neurodevelopmental Outcomes

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Perinatal white matter injury is associated with high rates of adverse neuropsychiatric outcomes and millions of years lived with disability. This review focuses on the macroscopic and microscopic features of perinatal white matter injury and how these relate to the proposed pathophysiology of this disease and adverse neurodevelopmental outcomes ...
Angela N. Viaene
wiley   +1 more source