Results 111 to 120 of about 82,581 (251)

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis

ACS Nano, 2017
Hyaluronan is a biologically active polymer, which can be formulated into nanoparticles. In our study, we aimed to probe atherosclerosis-associated inflammation by using hyaluronan nanoparticles and to determine whether they can ameliorate ...
Thijs J. Beldman, Max L. Senders, Amr Alaarg, C. Pérez-Medina, Jun Tang, Yi-Ming Zhao, François Fay, Jacqueline Deichmöller, B. Born, E. Desclos, N. N. van der Wel, R. Hoebe, F. Kohen, Elena Kartvelishvily, M. Neeman, T. Reiner, C. Calcagno, Z. Fayad, M. de Winther, E. Lutgens, W. Mulder, E. Kluza   +21 more
semanticscholar   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

High Mw Hyaluronan Inhibits Smoke Inhalation-Induced Lung Injury and Improves Survival

, 2011
Background and objective: High MW hyaluronan (HMW HA) as opposed to low MW hyaluronan (LMW HA) has been shown to have anti-inflammatory and anti- apoptotic effects.
HUANG, PEI-MING;LIU, YUNG-YANG, 黃培銘;劉永揚   +1 more
core  

Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics

Nature Communications
Immune surveillance involves the continual migration of antigen-scavenging immune cells from the tissues to downstream lymph nodes via lymphatic vessels.
Fouzia Bano, Suneale Banerji, Tao Ni, Dixy E. Green, Kalila R. Cook, Iain W. Manfield, Paul L. DeAngelis, Emanuele Paci, Martin Lepšík, Robert J. C. Gilbert, Ralf P. Richter, David G. Jackson   +11 more
doaj   +1 more source

Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer

Frontiers in Immunology, 2015
Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the ...
Toshiyuki eMurai
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Hyaluronan mediates sperm motility by enhancing phosphorylation of proteins including hyaluronan binding protein

, 1995
The present study was carried out to explore the mechanisms underlying hyaluronan-induced sperm motility. We demonstrate for the first time the enhanced cellular protein phosphorylation in hyaluronic acid stimulated cauda spermatozoa.
Datta, K., Ranganathan, S., Bharadwaj, A.   +2 more
core   +1 more source

Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.

Journal of the American Society of Nephrology, 2019
BACKGROUND A glycocalyx envelope consisting of proteoglycans and adhering proteins covers endothelial cells, both the luminal and abluminal surface. We previously demonstrated that short-term loss of integrity of the luminal glycocalyx layer resulted in ...
B. M. van den Berg, Gang-Qi Wang, M. Boels, M. C. Avramut, Erik Jansen, Wendy M. P. J. Sol, F. Lebrin, Anton Jan van Zonneveld, E. D. de Koning, H. Vink, H. Grone, P. Carmeliet, J. van der Vlag, T. Rabelink   +13 more
semanticscholar   +1 more source