Results 131 to 140 of about 82,581 (251)
Asia-Pacific Journal of Clinical Oncology, EarlyView.Hyaluronan‐mediated motility receptor (HMMR) promotes colorectal cancer progression by enhancing proliferation, migration, and invasion through activation of the PI3K/AKT/mTOR pathway. Targeting HMMR effectively suppresses these malignant phenotypes, highlighting its potential as a promising therapeutic target in colorectal carcinoma.
Cheng Shi +6 more
wiley +1 more source
Hyaluronan: a Simple Molecule with Complex Character
, 2011 This review aims to summarize the properties and applications of hyaluronan, a naturally-occurring, anionic polysaccharide. It provides an overview of its physic chemical properties, biosynthesis and biodegradation.
Koen P. Vercruysse
core +1 more source
Novel prognostic markers within the CD44‐stromal ligand network in pancreatic cancer
The Journal of Pathology: Clinical Research, 2019 The dense stroma in pancreatic cancer tumours is rich in secreted extracellular matrix proteins and proteoglycans. Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant isoform ...
Oskar Franklin +7 more
doaj +1 more source
Improving ARTs: Microfluidics as a Tool for Sperm Selection
Andrology, EarlyView.ABSTRACT Sperm selection is a critical step in assisted reproductive technology (ART), as sperm quality directly influences embryo quality. In vivo, the female reproductive tract imposes several physical and physiological barriers that favors only the most optimal spermatozoa reaching the fertilization site.
A. Pérez‐Gómez +7 more
wiley +1 more source
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2
, 2010 Failure of remyelination is largely responsible for sustained neurologic symptoms in multiple sclerosis (MS). MS lesions contain hyaluronan deposits that inhibit oligodendrocyte precursor cell (OPC) maturation.
Z. M. Harris +5 more
core +1 more source
British Journal of Pharmacology, EarlyView.The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral +3 more
wiley +1 more source
Layer-by-Layer Films from Hyaluronan and Amine-Modified Hyaluronan
, 2016 Hyaluronan is a polysaccharide that is increasingly investigated for its role in cellular adhesion and for the preparation of biomimetic matrices for tissue engineering.
Aurore Schneider (37683) +5 more
core +1 more source
Equine Veterinary Education, EarlyView.Summary Subchondral lucencies, also referred to as subchondral cystic lesions or osseous cyst‐like lesions, are radiographically identifiable defects of subchondral bone that remain an important cause of lameness and reduced athletic performance in horses.
C. Salazar‐Latorre +2 more
wiley +1 more source
International Journal of Cosmetic Science, EarlyView.Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak +5 more
wiley +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source