Hyaluronan-Arginine Enhanced Interaction Emerges from Distinctive Molecular Signature with Improved Electrostatics and Side-Chain Specificity [PDF]
arXiv, 2023 Hyaluronan, a sugar polymer found outside the plasma membrane, is a critical component of the extracellular matrix (ECM) scaffold. Hyaluronan's length and moderate negative charge aid in ECM entanglement and solubility. This allows it to effectively foster gel-like conditions, which are critical for supporting and protecting cells in various tissues ...
arxiv
Suppression of Aggregation in Natural-Semiflexible/Flexible Polyanion Mixtures, and Direct Check of the OSF Model using SANS [PDF]
Europhysics Letters (EPL) 83 (2008) 48002, 2009 Aggregation and other interactions are suppressed for a biological semiflexible polyelectrolyte, hyaluronan (HA), when it is embedded in a mixture with another negatively charged and flexible polyelectrolyte chain, sodium polystyrene sulfonate. We see directly HA only in the mixture using Small-Angle Neutron Scattering, isotopic labelling and contrast ...
arxiv +1 more source
Hyaluronan and self-assembling peptides as building blocks to reconstruct the extracellular environment in skin tissue [PDF]
, 2013 Funding for this study was provided by the Portuguese Foundation for Science and Technology (FCT, grant PTDC/EBB-BIO/114523/2009). D. S.
Agren +50 more
core +1 more source
The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity
Molecules, 2008 The dissolution of hyaluronan in water leads to its degradation, and as a resultits molecular weight decreases. The degradation of hyaluronan is mainly influenced bytemperature, solution composition, and also its pH.
VladimÃÂr Velebný +5 more
doaj +1 more source
Beads on a string: Structure of bound aggregates of globular particles and long polymer chains [PDF]
Soft Matter 11, 8092-8099 (2015), 2015 Macroscopic properties of suspensions, such as those composed of globular particles (e.g., colloidal or macromolecular), can be tuned by controlling the equilibrium aggregation of the particles. We examine how aggregation -- and, hence, macroscopic properties -- can be controlled in a system composed of both globular particles and long, flexible ...
arxiv +1 more source
Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression. [PDF]
, 2012 A hallmark of all solid tumor malignancies is the ability to invade the surrounding tissue and/or metastasize to distant sites. Tumors cells have altered signaling pathways which that to cytoskeleton activation and migration.
Bourguignon, Lilly YW
core +1 more source
Phospholipids and Hyaluronan: From Molecular Interactions to Nano- and Macroscale Friction
Colloids and Interfaces, 2022 Phospholipids and hyaluronan are two key biomolecules that contribute to the excellent lubrication of articular joints. Phospholipids alone and in combination with hyaluronan have also displayed low friction forces on smooth surfaces in micro- and ...
Sixuan Li +4 more
doaj +1 more source
Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]
, 2017 An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A +5 more
core +1 more source
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
International Journal of Cell Biology, 2015 Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the
Jaime M. Cyphert +2 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2022 Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang +3 more
doaj +1 more source