Results 41 to 50 of about 58,192 (295)

Role of hyaluronan and hyaluronan-binding proteins in human asthma [PDF]

Journal of Allergy and Clinical Immunology, 2011
The characteristics of human asthma are chronic inflammation and airway remodeling. Hyaluronan, a major extracellular matrix component, accumulates during inflammatory lung diseases, including asthma. Hyaluronan fragments stimulate macrophages to produce inflammatory cytokines.
Dianhua Jiang, Ting Xie, Ting Xie, Tony D. Church, Jiurong Liang, Paul W. Noble, Yoosun Jung, Simone Degan, Maura Leonard, Jennifer L. Ingram, Monica Kraft   +10 more
openaire   +3 more sources

The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity

Molecules, 2008
The dissolution of hyaluronan in water leads to its degradation, and as a resultits molecular weight decreases. The degradation of hyaluronan is mainly influenced bytemperature, solution composition, and also its pH.
Vladimír Velebný, Alena Pokopcová, Lenka Gřundělová, Marián Lehocký, Júlia Varhaníková, AleÅ¡ Mráček   +5 more
doaj   +1 more source

Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment

Frontiers in Immunology, 2019
Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often opposing functions. The biological activities of this polysaccharide depend on its molecular weight and the identity of interacting receptors.
Muhan Liu, Cornelia Tolg, E. Turley
semanticscholar   +1 more source

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro

International Journal of Molecular Sciences, 2020
The ovarian stroma, the microenvironment in which female gametes grow and mature, becomes inflamed and fibrotic with age. Hyaluronan is a major component of the ovarian extracellular matrix (ECM), and in other aging tissues, accumulation of low molecular
Jennifer E. Rowley, F. Amargant, L. Zhou, Anna M Galligos, Leah E. Simon, M. Pritchard, F. Duncan   +6 more
semanticscholar   +1 more source

Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing

Polymers, 2020
A high-molecular weight hyaluronan is oxidatively degraded by Cu(II) ions and ascorbate—the so called Weissberger biogenic oxidative system—which is one of the most potent generators of reactive oxygen species, namely •OH radicals.
K. Valachová, K. Švík, Csaba Biró, M. Collins, R. Jurčík, Ľ. Ondruška, L. Šoltés   +6 more
semanticscholar   +1 more source

Phospholipids and Hyaluronan: From Molecular Interactions to Nano- and Macroscale Friction

Colloids and Interfaces, 2022
Phospholipids and hyaluronan are two key biomolecules that contribute to the excellent lubrication of articular joints. Phospholipids alone and in combination with hyaluronan have also displayed low friction forces on smooth surfaces in micro- and ...
Sixuan Li, Lubica Macakova, Piotr Bełdowski, Per M. Claesson, Andra Dėdinaitė   +4 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells

Reproductive Biology and Endocrinology, 2022
Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang, Long Bai, Yi-Min Zhu, Peter C. K. Leung   +3 more
doaj   +1 more source

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Science Translational Medicine, 2019
Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target. HAlting liver fibrosis Hepatic stellate cells (HSCs) play a key role in liver fibrosis, a process marked by ...
Y. Yang, M. Noureddin, Cheng Liu, Koichiro Ohashi, S. Kim, Divya Ramnath, E. Powell, M. Sweet, Y. Roh, I‐Fang Hsin, N. Deng, Zhenqiu Liu, Jiurong Liang, E. Mena, D. Shouhed, R. Schwabe, D. Jiang, Shelly C. Lu, P. Noble, E. Seki   +19 more
semanticscholar   +1 more source

Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy

Cells, 2019
During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy.
Christina E. Lorén, Christen P. Dahl, Lan Do, Vibeke M. Almaas, Odd R. Geiran, Stellan Mörner, Urban Hellman   +6 more
doaj   +1 more source