Results 81 to 90 of about 58,192 (295)

Hyaluronan, a Crucial Regulator of Inflammation

Frontiers in Immunology, 2014
Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in regulating inflammation. Inflammation is associated with accumulation and turnover of hyaluronan polymers by multiple cell types. Increasingly through the years, HA
Aaron C Petrey, Carol A. de la Motte
doaj   +1 more source

Lung Hyaluronan as Assayed with a Biotinylated Hyaluronan-Binding Protein

Experimental Lung Research, 1994
This study was designed to define how hyaluronan (HA) is bound in lung tissue. Aliquots of lyophilized hamster lungs were extracted with 0.5 M NaCl (associative conditions) or 4 M guanidine . HCL (Gu . HCl) (dissociative conditions) or with water. Aliquots were also digested with Pronase in phosphate-buffered saline (PBS) or in dilute Tris buffer.
Gerard M. Turino, Bonnie Anderson Bray, Wenlie Hsu   +2 more
openaire   +3 more sources

Responsive Polyelectrolyte Brushes in Applications: Functions, Stimuli, and Design Considerations

Advanced Materials, EarlyView.
With advances in the synthesis of polyelectrolyte brushes, these coatings of surface‐grafted chains find uses in an increasing number of applications. This review summarizes three core aspects of these brushes: how they introduce functionality to surfaces; how external stimuli influence their properties; and what practical considerations should be ...
Leon A. Smook, Andreas Dahlin, Karin Schroën, Sissi de Beer   +3 more
wiley   +1 more source

Interactions between CD44 and hyaluronan in leukocyte trafficking

Frontiers in Immunology, 2015
Recruitment of leukocytes from the bloodstream to inflamed tissues requires a carefully regulated cascade of binding interactions between adhesion molecules on leukocytes and endothelial cells. Adhesive interactions between CD44 and hyaluronan have been
Braedon eMcDonald, Braedon eMcDonald, Paul eKubes   +2 more
doaj   +1 more source

Role of hyaluronan and hyaluronan-binding proteins in lung pathobiology

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2011
Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease. HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products, produced by hyaluronidase enzymes and reactive oxygen species, being implicated in several lung diseases, including acute lung injury, asthma, chronic obstructive pulmonary ...
Patrick A. Singleton, Frances E. Lennon
openaire   +3 more sources

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Role of endothelial hyaluronan in peritoneal membrane transport and disease conditions during peritoneal dialysis

Scientific Reports
Peritoneal membrane dysfunction in peritoneal dialysis (PD) is primarily attributed to angiogenesis; however, the integrity of vascular endothelial cells can affect peritoneal permeability.
Keisuke Kamiya, Naoyuki Hatayama, Mitsuhiro Tawada, Akimasa Asai, Mai Yamauchi, Hiroshi Kinashi, Shunnosuke Kunoki, Makoto Yamaguchi, Masashi Mizuno, Yasuhiro Suzuki, Masataka Banshodani, Takuji Ishimoto, Munekazu Naito, Hideki Kawanishi, Yasuhiko Ito   +14 more
doaj   +1 more source

Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices.

PLoS ONE, 2019
Certain bacterial species target the polysaccharide glycosaminoglycans (GAGs) of animal extracellular matrices for colonization and/or infection. GAGs such as hyaluronan and chondroitin sulfate consist of repeating disaccharide units of uronate and amino
Sayoko Oiki, Yusuke Nakamichi, Yukie Maruyama, Bunzo Mikami, Kousaku Murata, Wataru Hashimoto   +5 more
doaj   +1 more source

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

Polymers, 2019
Nano- and microfibers based on biopolymers are some of the most attractive issues of biotechnology due to their unique properties and effectiveness. Hyaluronan is well-known as a biodegradable, naturally-occurring polymer, which has great potential for ...
P. Snetkov, S. Morozkina, M. Uspenskaya, R. Olekhnovich   +3 more
semanticscholar   +1 more source