Results 121 to 130 of about 28,152 (259)
Layilin: a multifunctional hyaluronan receptor in physiology and pathology
Frontiers in OncologyLayilin (encoded by LAYN ), a C-type lectin transmembrane receptor, serves as a critical molecular bridge between extracellular matrix (ECM) sensing and intracellular signaling through its interaction with cytoskeletal adaptors. Initially identified for its cytoskeletal functions, layilin has
Jin, Chenchen, Zong, Yunfeng
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The FEBS Journal, EarlyView.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2016 Background & Aims: Crohnâs Disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Fibrosis, a serious complication of CD, occurs when activated intestinal fibroblasts deposit excessive amounts of extracellular matrix (ECM) in ...
Artin Soroosh +5 more
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Hyaluronan Receptors on Liver Endothelial Cells.
Trends in Glycoscience and Glycotechnology, 1996 結合組織の多糖類であるヒアルロナン (ヒアルロン酸、HA)は、肝臓の内皮細胞 (LEC) が受容体を介したエンドサイトーシスを行うことにより、循環系から極めて効果的に除かれる。肝硬変のような肝疾患が起こると、LECによるHAの取り込みが減少してHAの血清濃度が増加する。少なくとも2種の異なる受容体活性がLEC表層には存在する。そのひとつはカルシウム依存性で直接にはエンドサイトーシスには関与していないようである。もう一つはカルシウム非依存性でエンドサイトーシスを仲介する。受容体はコンドロイチン硫酸やデキストラン硫酸のようなHA以外のリガンドも認識するので、その点でスキャベンジャー受容体に似ている。高分子量HAは低分子量HAより受容体に対して高い親和性を持ち、受容体が認識する最小のオリゴ糖は6糖である ...
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Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, EarlyView.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
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Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium.
, 2001 The glycosaminoglycan hyaluronan is a key substrate for cell migration in tissues during inflammation, wound healing, and neoplasia. Unlike other matrix components, hyaluronan (HA) is turned over rapidly, yet most degradation occurs not locally but ...
Clasper, S +4 more
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Hyaluronic acid metabolism and chemotherapy resistance: recent advances and therapeutic potential
Molecular OncologyHyaluronic acid (HA) is a major component of the extracellular matrix, providing essential mechanical scaffolding for cells and, at the same time, mediating essential biochemical signals required for tissue homeostasis.
Zhanhong Liu +6 more
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Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, EarlyView.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
Are hyaluronan receptors involved in three-dimensional cell migration?
, 2011 Hyaluronan (HA), an unbranched polysaccharide consisting of repeated glucuronic acid/Nacetylglucosamine disaccharide units, is ubiquitously present in the extracellular matrix of many tissues (for a more comprehensive review see: Fraser et al., 1997 ...
Hayen, W., Nehls, Volker
core