Results 161 to 170 of about 28,152 (259)

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions

open access: yesEuropean Journal of Immunology, Volume 56, Issue 6, June 2026.
Using cyclic multiplex microscopy in an IL‐33‐driven type 2 inflammation model, we validated a spatial workflow mapping rare lung ILCs. High‐dimensional analysis revealed a conserved peri‐lymphatic niche at early time points of inflammation where ILC2s and myeloid cells co‐localize with LYVE1+ vessels, highlighting a structured immunological ...
Sandy Kroh   +10 more
wiley   +1 more source

Paclitaxel-hyaluronan hydrosoluble bioconjugate: Mechanism of action in human bladder cancer cell lines

open access: yes, 2012
OBJECTIVES: A previously described hydrosoluble paclitaxel-hyaluronan bioconjugate appears particularly well suited for treatment of superficial bladder cancer because of its in vitro cytotoxic profile against urothelial carcinoma (UC) cell lines and in
Bassi, Pierfrancesco
core  

Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD

open access: yesEuropean Journal of Immunology, Volume 56, Issue 6, June 2026.
This review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Jiaqi Tang   +2 more
wiley   +1 more source

Nephronectin regulates cardiac valve development via BMP4-HAS2 signaling in zebrafish

open access: yes, 2011
It has been estimated that about 1% of live births carry severe congenital heart defects and 20-30% among them have valve malformations. Despite its medical importance the underlying cause of many valvular diseases remains undiscovered.
Patra, Chinmoy (Dr.)
core  

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody   +4 more
wiley   +1 more source

Hyaluronan role in Xenopus laevis visceral skeleton morphogenesis

open access: yes
Hyaluronan (HA) is a crucial glycosaminoglycan of vertebrate extracellular matrix. In dynamic cellular systems, such as embryonic development, tissue regeneration and tumorigenesis, HA has been shown to influence cell behaviour, including cell migration,
CASINI, PAOLA
core  

Hyaluronan, RHAMM mediated signal transduction : functions in focal adhesion turnover, cell locomotion and tumorigenesis

open access: yes, 1997
Extracellular matrix (ECM) molecules and their receptors are important regulators of adhesion, migration, cytoskeletal organization, gene expression, growth and differentiation.
Hall, Christine L.
core  

Hyaluronan in cardiac disease: implications for the extracellular matrix beyond collagen. [PDF]

open access: yesAm J Physiol Heart Circ Physiol
Ramalingam AR, Howard CM, Jones SP.
europepmc   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu   +16 more
wiley   +1 more source

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