Results 161 to 170 of about 27,596 (198)
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Hyaluronan and its receptors in mucoepidermoid carcinoma
Head and Neck, 2006Hyaluronan (HA) is a prominent extracellular matrix component undergoing continuous production and degradation. Increased HA levels have been described in a variety of tumors. The objective of this study was to examine the staining patterns of HA and two of its associated receptors (CD44 and HARE) in relation to the metastatic potential of ...
Richard O, Wein +6 more
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The International Journal of Biochemistry & Cell Biology, 2002
CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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Internalization of the Hyaluronan Receptor CD44 by Chondrocytes
Experimental Cell Research, 1999Chondrocytes express CD44 as a primary receptor for the matrix macromolecule hyaluronan. Hyaluronan is responsible for the retention and organization of proteoglycan within cartilage, and hyaluronan-chondrocyte interactions are important for the assembly and maintenance of the cartilage matrix.
D J, Aguiar, W, Knudson, C B, Knudson
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Receptors for Hyaluronan on Corneal Endothelial Cells
Experimental Eye Research, 1994Previous investigations suggest that the corneal endothelium has specific binding sites for hyaluronan (HYA). In the present study, biochemical and immunological techniques were used to characterize these binding sites and to compare them with the liver endothelial cell (LEC) HYA receptor.
N, Forsberg +4 more
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Regulation of hyaluronan production by β2 adrenergic receptor signaling
Biochemical and Biophysical Research Communications, 2021Hyaluronan (HA), the main component of the extracellular matrix, is involved in tissue elasticity and cell scaffolding, and in progression of conditions such as cancer, inflammation and wound healing. Signaling by G protein coupled receptor (GPCR) activation increases expression of hyaluronan synthase (HAS) and HA production. The β2 adrenergic receptor
Yoshiyuki, Kuroda, Hideyoshi, Higashi
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Study of Hyaluronan-Binding Proteins and Receptors Using Iodinated Hyaluronan Derivatives
2003This chapter detailed methodology for the purification of high molecular weight HA, as well as procedures to fragment the HA to prepare large oligosaccharides in the range of 40,000-80,000 Da. The aforementioned procedures used to prepare HA-alkylamine and HA-Bolton-Hunter adducts, as well as 125I-labeled HA, have been very reproducible, and the latter
Carl T, McGary +2 more
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Hyaluronan Synthases, Hyaluronan and Its CD44 Receptors in the Posterior Segment of Rabbit Eye
Ophthalmologica, 2005To understand the possible roles of the hyaluronan synthetase (HAS)/hyaluronan (HA)/CD44 signaling system in the posterior eye segment, we investigated the expression of rabbit HAS isoforms and CD44 mRNA by RT-PCR and the level of HA by using HA assay and immunohistochemistry. HA was detectable in vitreous, retina and choroid.
Masatoshi, Murata, Saburo, Horiuchi
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Hyaluronan-binding receptors: possible involvement in osteoarthritis
Modern Rheumatology, 2008Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA.
Sharon, Dunn +3 more
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The regulation of sperm motility by a novel hyaluronan receptor
Fertility and Sterility, 1994To determine if a novel receptor for hyaluronan, termed RHAMM, is responsible for the previously observed increase in sperm locomotion in response to hyaluronan and to assess whether expression of the RHAMM protein is involved in sperm motility.The RHAMM protein was localized on human sperm by immunofluorescence of fixed cells, fluorescence-activated ...
B S, Kornovski +3 more
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Blood, 1999
AbstractAlthough the mechanism(s) underlying mobilization of hematopoietic progenitor cells (HPCs) is unknown, detachment from the bone marrow (BM) microenvironment and motility are likely to play a role. This work analyzes the motile behavior of HPCs and the receptors involved. CD34+45lo/medScatterlo/med HPCs from granulocyte colony-stimulating factor
L M, Pilarski +7 more
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AbstractAlthough the mechanism(s) underlying mobilization of hematopoietic progenitor cells (HPCs) is unknown, detachment from the bone marrow (BM) microenvironment and motility are likely to play a role. This work analyzes the motile behavior of HPCs and the receptors involved. CD34+45lo/medScatterlo/med HPCs from granulocyte colony-stimulating factor
L M, Pilarski +7 more
openaire +2 more sources