Results 171 to 180 of about 28,152 (259)

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Organ Medicine, Volume 3, Issue 2, Page 76-86, June 2026.
Cancer‐associated fibroblasts (CAFs) are key regulators of the pancreatic tumor microenvironment. Through metabolic reprogramming, CAFs support tumor growth by providing nutrients and remodeling extracellular matrix. CAF heterogeneity, including myCAF, iCAF, and apCAF subsets, contributes to immune modulation and therapeutic resistance.
Ziyi Qin, Jinyang Ma, Rui Ju, Lei Guo
wiley   +1 more source

Importance of Hyaluronan-CD44 Signaling in Tumor Progression [Elektronisk resurs] : Crosstalk with TGFβ and PDGF-BB Signaling

, 2013
In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor ...
Porsch, Helena,, Heldin, Paraskevi,, Orian-Rousseau, Véronique,   +2 more
core  

Hyaluronan induces ERK activation with minimal transcriptomic changes in pancreatic α-cells. [PDF]

Biochem Biophys Rep
Sonoyama S, Mizokami A, Sano T, Jimi E, Moriyama M, Kanematsu T.   +5 more
europepmc   +1 more source

Loss of Brain‐Derived Estrogen Is Associated With Sex‐ and Age‐Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression

Aging Cell, Volume 25, Issue 6, June 2026.
Age, sex, and estrogen loss are widely recognized risk factors for Alzheimer's disease. Here, we show that brain‐specific aromatase knockout (bArKO) and the resulting estrogen loss lead to memory impairment, reduced social interaction, and extracellular environment dysregulation selectively in aged female mice, but not in young female or male mice ...
Natalie C. Piehl, Ariel W. Halle, Guadalupe Rodriguez, Andrea Locci, Stacy Kujawa, Caroline Haywood, John Coon V, Ross P. McNally, Zaina A. Karim, Tianming You, Hongxin Dong, Serdar E. Bulun, Hong Zhao   +12 more
wiley   +1 more source

Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer [Elektronisk resurs]

, 2017
Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface ...
Schaefer, Liliana,, Heldin, Paraskevi,, Mehić, Merima,, Heldin, Carl-Henrik,   +3 more
core  

The Matrisome as an Immunomodulator: A Role Far Beyond Its Structural Support. [PDF]

Biomolecules
Quan T.
europepmc   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source

Hyaluronic Acid-Based Biomaterials in Tissue Engineering: From Molecular Properties to Re-Generative Applications. [PDF]

J Funct Biomater
Su CM, Shie MY, Huang WN, Chiu FJ, Chen HK, Chen YW, Shen YF.   +6 more
europepmc   +1 more source

Dengue NS1 as a Driver of Immune-Mediated Pathogenesis. [PDF]

Trop Med Infect Dis
Wanigarathna US, Rajapakse S, Pathirana SL, Handunnetti SM, Nitsche A, Fernando N.   +5 more
europepmc   +1 more source

Perinatal White Matter Injury: Connecting Histology, Pathophysiology and Neurodevelopmental Outcomes

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Perinatal white matter injury is associated with high rates of adverse neuropsychiatric outcomes and millions of years lived with disability. This review focuses on the macroscopic and microscopic features of perinatal white matter injury and how these relate to the proposed pathophysiology of this disease and adverse neurodevelopmental outcomes ...
Angela N. Viaene
wiley   +1 more source