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Hyaluronan receptors involved in cytokine induction in monocytes

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The hyaluronan receptor, CD44

The International Journal of Biochemistry & Cell Biology, 2002
CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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Receptors for Hyaluronan on Corneal Endothelial Cells

Experimental Eye Research, 1994
Previous investigations suggest that the corneal endothelium has specific binding sites for hyaluronan (HYA). In the present study, biochemical and immunological techniques were used to characterize these binding sites and to compare them with the liver endothelial cell (LEC) HYA receptor.
N, Forsberg   +4 more
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Hyaluronan and its receptors in mucoepidermoid carcinoma

Head & Neck, 2006
Hyaluronan (HA) is a prominent extracellular matrix component undergoing continuous production and degradation. Increased HA levels have been described in a variety of tumors. The objective of this study was to examine the staining patterns of HA and two of its associated receptors (CD44 and HARE) in relation to the metastatic potential of ...
Richard O, Wein   +6 more
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Hyaluronan-binding receptors: possible involvement in osteoarthritis

Modern Rheumatology, 2008
Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA.
Sharon, Dunn   +3 more
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Regulation of hyaluronan production by β2 adrenergic receptor signaling

Biochemical and Biophysical Research Communications, 2021
Hyaluronan (HA), the main component of the extracellular matrix, is involved in tissue elasticity and cell scaffolding, and in progression of conditions such as cancer, inflammation and wound healing. Signaling by G protein coupled receptor (GPCR) activation increases expression of hyaluronan synthase (HAS) and HA production. The β2 adrenergic receptor
Yoshiyuki, Kuroda, Hideyoshi, Higashi
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