Results 231 to 240 of about 28,152 (259)

Study of Hyaluronan-Binding Proteins and Receptors Using Iodinated Hyaluronan Derivatives

2003
This chapter detailed methodology for the purification of high molecular weight HA, as well as procedures to fragment the HA to prepare large oligosaccharides in the range of 40,000-80,000 Da. The aforementioned procedures used to prepare HA-alkylamine and HA-Bolton-Hunter adducts, as well as 125I-labeled HA, have been very reproducible, and the latter
Carl T, McGary, Janet A, Weigel, Paul H, Weigel   +2 more
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Regulation of hyaluronan production by β2 adrenergic receptor signaling

Biochemical and Biophysical Research Communications, 2021
Hyaluronan (HA), the main component of the extracellular matrix, is involved in tissue elasticity and cell scaffolding, and in progression of conditions such as cancer, inflammation and wound healing. Signaling by G protein coupled receptor (GPCR) activation increases expression of hyaluronan synthase (HAS) and HA production. The β2 adrenergic receptor
Yoshiyuki, Kuroda, Hideyoshi, Higashi
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Hyaluronan Synthases, Hyaluronan and Its CD44 Receptors in the Posterior Segment of Rabbit Eye

Ophthalmologica, 2005
To understand the possible roles of the hyaluronan synthetase (HAS)/hyaluronan (HA)/CD44 signaling system in the posterior eye segment, we investigated the expression of rabbit HAS isoforms and CD44 mRNA by RT-PCR and the level of HA by using HA assay and immunohistochemistry. HA was detectable in vitreous, retina and choroid.
Masatoshi, Murata, Saburo, Horiuchi
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Hyaluronan-binding receptors: possible involvement in osteoarthritis

Modern Rheumatology, 2008
Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA.
Sharon, Dunn, Oleg V, Kolomytkin, David D, Waddell, Andrew A, Marino   +3 more
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The regulation of sperm motility by a novel hyaluronan receptor

Fertility and Sterility, 1994
To determine if a novel receptor for hyaluronan, termed RHAMM, is responsible for the previously observed increase in sperm locomotion in response to hyaluronan and to assess whether expression of the RHAMM protein is involved in sperm motility.The RHAMM protein was localized on human sperm by immunofluorescence of fixed cells, fluorescence-activated ...
B S, Kornovski, J, McCoshen, J, Kredentser, E, Turley   +3 more
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Potential Role for Hyaluronan and the Hyaluronan Receptor RHAMM in Mobilization and Trafficking of Hematopoietic Progenitor Cells

Blood, 1999
AbstractAlthough the mechanism(s) underlying mobilization of hematopoietic progenitor cells (HPCs) is unknown, detachment from the bone marrow (BM) microenvironment and motility are likely to play a role. This work analyzes the motile behavior of HPCs and the receptors involved. CD34+45lo/medScatterlo/med HPCs from granulocyte colony-stimulating factor
L M, Pilarski, E, Pruski, J, Wizniak, D, Paine, K, Seeberger, M J, Mant, C B, Brown, A R, Belch   +7 more
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Characterization and purification of the hyaluronan-receptor on liver endothelial cells

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
In order to characterize the proteins on liver endothelial cells that bind hyaluronan (HYA), liver endothelial cells were surface-iodinated with 125I, solubilized by Triton X-100 and passed through a column containing HYA coupled to agarose. The column was washed and eluted with HYA-oligosaccharides.
N, Forsberg, S, Gustafson
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Characterization of the murine gene encoding the hyaluronan receptor RHAMM

Gene, 1995
We describe the isolation and characterization of the murine gene encoding RHAMM, a hyaluronan receptor which regulates focal adhesion turnover, is required for cell locomotion and is a critical downstream regulator of ras transformation. The RHAMM gene spans at least 20 kb and comprises 14 exons ranging in size from 75 to 1099 bp.
J, Entwistle, S, Zhang, B, Yang, C, Wong, Q, Li, C L, Hall, J, A, M, Mowat, A H, Greenberg, E A, Turley   +9 more
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Histochemical studies of hyaluronan and the hyaluronan receptor ICAM-1 in psoriasis.

International journal of tissue reactions, 1997
Histochemical stainings of frozen sections of human normal and psoriatic skin were used to study the localization of hyaluronan (HA) and intercellular adhesion molecule 1 (ICAM-1). HA staining was found in all areas of the skin, with the exception of the stratum corneum, in both normal and psoriatic cases without any apparent quantitative differences ...
S, Gustafson, T, Wikström, L, Juhlin
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Immunolocalization of the hyaluronan receptor CD44 in the reproductive tract of the mare

Theriogenology, 2011
Hyaluronan (HA), a glycosaminoglycan, is a major component of the pericellular matrix which envelopes mammalian cells. Binding of hyaluronan to one of its specific receptors, CD44, modulates transduction of intracellular signals which direct a variety of processes, including embryogenesis, wound healing, inflammation, and neoplasia. Since regulation of
Rodriguez Hurtado, I., Stewart, A. J., Wolfe, D. F., Caldwell, F. J., Harrie, M., Whitley, E. M.   +5 more
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