Structure, substrate recognition and initiation of hyaluronan synthase. [PDF]
Nature, 2022 Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Maloney FP +9 more
europepmc +7 more sources
A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. [PDF]
Int J Mol Sci, 2022 Hyaluronan (HA), an essential component of the extracellular matrix of the skin, is synthesized by HA synthases (HAS1-3). To date, epidermal HA has been considered a major player in regulating cell proliferation and differentiation.
Ota Y +4 more
europepmc +5 more sources
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. [PDF]
Sci Transl Med, 2019 Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target. HAlting liver fibrosis Hepatic stellate cells (HSCs) play a key role in liver fibrosis, a process marked by ...
Yang YM +19 more
europepmc +8 more sources
Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo. [PDF]
Sci Rep, 2022 Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Tonge JJ +7 more
europepmc +2 more sources
Hyaluronic acid production and characterization by novel Bacillus subtilis harboring truncated Hyaluronan Synthase. [PDF]
AMB Express, 2022 Hyaluronic Acid (HA) is a natural biopolymer that has important physiological and industrial applications due to its viscoelastic and hydrophilic characteristics. The responsible enzyme for HA production is Hyaluronan synthase (HAS).
Amjad Zanjani FS +7 more
europepmc +2 more sources
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. [PDF]
Exp Mol Med, 2022 Liver fibrosis occurs during wound healing after repeated liver injury and is characterized by extensive extracellular matrix deposition. We previously identified hyaluronan synthase 2 (HAS2) as a driver of liver fibrosis and hepatic stellate cell (HSC ...
Kim SM +7 more
europepmc +2 more sources
CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. [PDF]
Pediatr Res, 2022 Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an unfortunate ...
Mayer CA +11 more
europepmc +2 more sources
Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells. [PDF]
Int J Mol Sci, 2021 Skin barrier damage is present in the patients with hereditary disorders of the magnesium channel, but the molecular mechanism has not been fully understood.
Marunaka K +6 more
europepmc +2 more sources
Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2. [PDF]
Sci Rep, 2021 Hyaluronic acid (HA), a unique polysaccharide with excellent Physico-chemical properties, is broadly used in pharmaceutical, biomedical, and cosmetic fields. It is widely present in all vertebrates, certain bacterial strains, and even viruses while it is
Nazeri A +5 more
europepmc +2 more sources
Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway. [PDF]
Cancer Cell Int, 2021 Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency.
Li M, Jin S, Cao Y, Xu J, Zhu S, Li Z.
europepmc +2 more sources