Results 131 to 140 of about 10,590 (199)

Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2-AS1. [PDF]

J Biol Chem, 2020
Caon I, Bartolini B, Moretto P, Parnigoni A, Caravà E, Vitale DL, Alaniz L, Viola M, Karousou E, De Luca G, Hascall VC, Passi A, Vigetti D.   +12 more
europepmc   +1 more source

Nitrilotriacetic Acid Functionalized Microgels for Efficient Immobilization of Hyaluronan Synthase

Enzymes play a vital role in synthesizing complex biological molecules like hyaluronic acid (HA). Immobilizing enzymes on support materials is essential for their efficient use and reuse in multiple cycles.
Sommerfeld, Isabel K., Pich, Andrij, Sommerfeld, Isabel Katja, Pich, Andrij; id_orcid, Elling, Lothar, Dalken, Esther Maria   +5 more
core   +1 more source

Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis. [PDF]

J Biol Chem, 2020
Terazawa S, Nakano M, Yamamoto A, Imokawa G.   +3 more
europepmc   +1 more source

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways

, 2018
Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption, and tissue wounding, and by specific nerve terminals firing. Increased
Tammi, M. I. (Markku I.), Rauhala, L. (Leena), Tammi, R. H. (Raija H.), Bart, G. (Geneviève), Oikari, S. (Sanna), Jokela, T. (Tiina), Kärnä, R. (Riikka), Takabe, P. (Piia), Pasonen-Seppänen, S. (Sanna)   +8 more
core  

Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism. [PDF]

J Biol Chem, 2019
Terabe K, Ohashi Y, Tsuchiya S, Ishizuka S, Knudson CB, Knudson W.   +5 more
europepmc   +1 more source

Efficiencies of fragmentation of glycosaminoglycan chloramides of the extracellular matrix by oxidizing and reducing radicals: potential site-specific targets in inflammation? [PDF]

, 2013
Parsons, BJ, Paterson, Andrew W. J., Akeel, A, Al-Assaf, S, Edge, R, Akeel, Almabrok, Sibanda, Sambulelwe, Edge, Ruth; id_orcid, Parsons, Barry J., Al-Assaf, Saphwan, Sibanda, S, Paterson, AW, Martin, SW, Martin, Stephen W.   +13 more
core   +1 more source

An Experimental study by Estimation of the Level of Hyaluronan Synthase in patients Suffering from Osteoarthritis of Knee, treated with Bryonia Alba

, 2018
Cases of Osteoarthritis with predefined symptoms of Bryonia alba have been taken up for the study by estimating the level of Hyaluronan synthase before and after treatment. AIMS AND OBJECTIVES: 1.
Aathira, V Nair
core  

Hyaluronan synthase 2 (HAS2); hyaluronidase 2 (HYAL2) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes

, 2002
Hyaluronan is a major component of the epidermal extracellular matrix, is actively synthesized by keratinocytes and shows fast matrix turnover in the stratified epithelium. We probed the importance of hyaluronan synthesis in keratinocytes by establishing
Sironen, Reijo,, Tammi, Markku,, Lammi, Mikko,, Hyttinen, Mika,, Hascall, Vincent,, Törrönen, Kari,, Midura, Ronald,, Pelkonen, Jukka,, Luukkonen, Merja,, Rilla, Kirsi,, Tammi, Raija,   +10 more
core  

Targeting hyaluronan synthesis enhances the therapeutic effectiveness of biologics in inflammatory bowel disease

JCI Insight
Although biologics have been revolutionizing the treatment of inflammatory bowel diseases (IBD) over the past decade, a significant number of patients still fail to benefit from these drugs.
Peng Xiao, Zhehang Chen, Xuechun Cai, Wenhao Xia, Xia Liu, Zhangfa Song, Huijuan Wang, Yuening Zhao, Youling Huang, Yu Zhang, Ke Guo, Haotian Chen, Rongbei Liu, Changcheng Meng, Yanfei Fang, Yunkun Lu, Qian Cao   +16 more
doaj   +1 more source