Results 111 to 120 of about 10,590 (199)

Autophagy regulates hyaluronan synthase 2 levels in vascular endothelial cells [PDF]

, 2018
Abstract Hyaluronan is emerging as a key player regulating wound repair, inflammation, and angiogenesis. Of the three hyaluronan synthases (HAS1-3), HAS2 is the main driver of tumorigenicity by enhancing hyaluronan deposition. We discovered that HAS2 was degraded in vascular endothelial cells via autophagy, a catabolic process evoked by
Chen, Carolyn G., Gubbiotti, Maria A., Han, Xiaorui, Yu, Yanglei, Linhardt, Robert J., Iozzo, Renato V.   +5 more
openaire   +1 more source

Characterization of PmHS2 glycosyltransferases for the controlled synthesis of heparosan : a precursor of heparin and heparan sulfate

, 2011
Heparin (Hep), a highly sulfated and complex glycosaminoglycan polysaccharides, is worldwide used as an anticoagulant compound to prevent blood clotting during surgery.
Chavaroche, A.A.E.
core  

Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells

Matrix Biology Plus, 2019
High levels of hyaluronan (ΗΑ), a major extracellular matrix (ECM) glycosaminoglycan, have been correlated with poor clinical outcome in several malignancies, including breast cancer.
Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos   +9 more
doaj   +1 more source

Jatrorrhizine Isolated from Phellodendron amurense Improves Collagen Homeostasis in CCD-986sk Human Dermal Fibroblast Cells

Cosmetics
Jatrorrhizine is one of the major bioactive compounds found in Phellodendron amurense. Previous studies have reported various health benefits of jatrorrhizine, but little is known about its effect on skin health.
Junhyo Cho
doaj   +1 more source

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Frontiers in Physiology, 2018
Background: Pulmonary hypertension (PH) is a devastating and progressive disease characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and remodeling of the lung vasculature.
Tinne C. J. Mertens, Ankit Hanmandlu, Ly Tu, Ly Tu, Carole Phan, Carole Phan, Scott D. Collum, Ning-Yuan Chen, Tingting Weng, Jonathan Davies, Chen Liu, Holger K. Eltzschig, Soma S. K. Jyothula, Keshava Rajagopal, Yang Xia, Ashrith Guha, Brian A. Bruckner, Michael R. Blackburn, Christophe Guignabert, Christophe Guignabert, Harry Karmouty-Quintana   +20 more
doaj   +1 more source

Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. [PDF]

Exp Mol Med, 2022
Kim SM, Song GY, Shim A, Lee JH, Eom CB, Liu C, Yang YM, Seki E.   +7 more
europepmc   +1 more source

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways

, 2018
Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption, and tissue wounding, and by specific nerve terminals firing. Increased
Tiina Jokela, Bart, Geneviève, Kärnä, Riikka, Geneviève Bart, Leena Rauhala, Sanna Oikari, Raija H. Tammi, Rauhala, Leena, Tammi, Markku I., Oikari, Sanna, Takabe, Piia, Riikka Kärnä, Piia Takabe, Markku I. Tammi, Sanna Pasonen-Seppänen, Jokela, Tiina, Pasonen-Seppänen, Sanna, Tammi, Raija H.   +17 more
core   +1 more source

Photoaging Protective Effects of Quercitrin Isolated from ‘Green Ball’ Apple Peel

Horticulturae
Premature skin aging, also known as photoaging, refers to the changes in the structure and function of the skin caused by chronic sun exposure. The ultraviolet radiation in sunlight is one of the key factors that cause photoaging.
Eun-Ho Lee, Junhyo Cho, In-Kyu Kang
doaj   +1 more source

Maple water (Acer saccharum sap), a traditional North American beverage: anti-inflammatory activity and potential functional relevance for skin health

Journal of Ethnic Foods
Maple water (Acer saccharum sap) is a traditional seasonal beverage consumed in North America; however, its functional relevance as a bioactive dietary resource remains poorly understood.
Ye-Lim You, Ha-Jun Byun, Kisoo Han, Hyo Chul An, Hyeon-Son Choi   +4 more
doaj   +1 more source

Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma. [PDF]

Arch Med Sci, 2023
Akgun H, Metintas S, Ak G, Demirkol Canlı S, Isbilen M, Gure AO, Metintas M.   +6 more
europepmc   +1 more source