Results 91 to 100 of about 10,590 (199)

IL-13 is a driver of COVID-19 severity

JCI Insight, 2021
Immune dysregulation is characteristic of the more severe stages of SARS-CoV-2 infection. Understanding the mechanisms by which the immune system contributes to COVID-19 severity may open new avenues to treatment.
Alexandra N. Donlan, Tara E. Sutherland, Chelsea Marie, Saskia Preissner, Benjamin T. Bradley, Rebecca M. Carpenter, Jeffrey M. Sturek, Jennie Z. Ma, G. Brett Moreau, Jeffrey R. Donowitz, Gregory A. Buck, Myrna G. Serrano, Stacey L. Burgess, Mayuresh M. Abhyankar, Cameron Mura, Philip E. Bourne, Robert Preissner, Mary K. Young, Genevieve R. Lyons, Johanna J. Loomba, Sarah J. Ratcliffe, Melinda D. Poulter, Amy J. Mathers, Anthony J. Day, Barbara J. Mann, Judith E. Allen, William A. Petri Jr.   +26 more
doaj   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Nucleotide sequence of Japanese eel hyaluronan synthase 2 (eHAS2) with the predicted amino acid sequence given below.

, 2014
Nucleotide sequence of Japanese eel hyaluronan synthase 2 (eHAS2) with the predicted amino acid sequence given below.
Kazuharu Nomura (206077), Yutaka Kawakami (206073), Hideki Tanaka (206080)   +2 more
core   +1 more source

Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis [PDF]

, 2011
Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated
T. Pavicic, V. Tarabin, Korting, Hans Christian, Malle, B., Pavicic, T., G. Gauglitz, T. Köhler, Korting, H. C., Tarabin, V., Wegmann, M., B. Malle, M. Wegmann, G. Schmitz, Schmitz, G., M. Farwick, Gauglitz, Gerd, K. Schwach-Abdellaoui, Malle, D., Schmitz, Gerd, Schwach-Abdellaoui, K., Gauglitz, G., Köhler, T., Farwick, M., H.C. Korting   +23 more
core   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, Volume 604, Issue 11, Page 4302-4317, 1 June 2026.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.

The Journal of biological chemistry, 2004
The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Hiroko, Hoshi, Hiroaki, Nakagawa, Susumu, Nishiguchi, Kazumichi, Iwata, Kenichi, Niikura, Kenji, Monde, Shin-Ichiro, Nishimura   +6 more
openaire   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Increased Hyaluronan Synthase-2 mRNA Expression and Hyaluronan Accumulation with Choroidal Thickening: Response during Recovery from Induced Myopia [PDF]

Investigative Opthalmology & Visual Science, 2010
Several studies have convincingly shown that in chicks, compensation for imposed focus involves immediate changes in choroid thickness. The molecular events associated with choroidal thickening and the regulation of the choroidal response are largely unknown.Form-deprivation myopia was induced in the right eyes of 2-day-old chicks by the application of
Jody A Summers, Rada, Allan F, Wiechmann, Lindsey R, Hollaway, Bruce A, Baggenstoss, Paul H, Weigel   +4 more
openaire   +2 more sources

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source