Results 81 to 90 of about 10,107 (167)

Postbiotics: An Overview and Recommendations for Improved Reporting

Molecular Nutrition &Food Research, Volume 70, Issue 14, 29 July 2026.
Human clinical trials of postbiotics and corresponding preclinical evidence were evaluated. Key reporting gaps identified included inconsistent terminology, incomplete inactivation method reporting, variable dosing information, insufficient quality‐control data, and inadequate taxonomic characterization.
Mehreen Anjum, Arthur C. Ouwehand
wiley   +1 more source

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp, Linda B. Pratt, Callan J. Schroder, Joseph D. Staab, Grant D. Hatcher, Joshua T. McWilliams, Michael C. Wilhelm, Ashley C. Texel, Edward N. Harris   +8 more
wiley   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, Volume 56, Issue 7, Page 769-783, July 2026.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Clinical significance of hyaluronan levels and its pro-osteogenic effect on mesenchymal stromal cells in myelodysplastic syndromes

Journal of Translational Medicine, 2018
Background Hyaluronan (HA), a major component of the extracellular matrix, has been proven to play a crucial role in tumor progression. However, it remains unknown whether HA exerts any effects in myelodysplastic syndromes (MDS).
Cheng-Ming Fei, Juan Guo, You-Shan Zhao, Si-Da Zhao, Qing-Qing Zhen, Lei Shi, Xiao Li, Chun-Kang Chang   +7 more
doaj   +1 more source

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
doaj   +1 more source

Hyaluronic acid−CD44 signaling from decidual stromal cells orchestrates dNK1 differentiation and immune tolerance in early pregnancy

Frontiers in Immunology
IntroductionSpontaneous abortion (SA) is closely associated with immune homeostasis of decidual natural killer (dNK) cells at the maternal-fetal interface, yet how decidual stromal cells (DSCs) educate NK cells remains incompletely understood.
Di Wang, Jiawei Zhu, Qingzhi Wang, Lingyun Shi, Yehua He, Zili Jin, Zili Jin, Wenjun Chen, Xiaocong Chen, Shenjun Chen, Hong Li, Ce Zhang, Rui Zhu, Rui Zhu   +13 more
doaj   +1 more source

Autophagy regulates hyaluronan synthase 2 levels in vascular endothelial cells [PDF]

, 2018
Abstract Hyaluronan is emerging as a key player regulating wound repair, inflammation, and angiogenesis. Of the three hyaluronan synthases (HAS1-3), HAS2 is the main driver of tumorigenicity by enhancing hyaluronan deposition. We discovered that HAS2 was degraded in vascular endothelial cells via autophagy, a catabolic process evoked by
Chen, Carolyn G., Gubbiotti, Maria A., Han, Xiaorui, Yu, Yanglei, Linhardt, Robert J., Iozzo, Renato V.   +5 more
openaire   +1 more source

Helicobacter pylori activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis

Gut Microbes
Background Metabolic reprogramming and epigenetic alterations play important roles in driving tumor microenvironment (TME) remodeling and immune evasion in gastric cancer (GC). Histone lactylation links glycolytic metabolism to transcriptional regulation,
Han Chen, Yan Wang, Zizhuang Wang, Wei Su, Yuting Shao, Guoxin Zhang, Zi Wang, Yixin Ge, Xiaoying Zhou   +8 more
doaj   +1 more source

Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells

Matrix Biology Plus, 2019
High levels of hyaluronan (ΗΑ), a major extracellular matrix (ECM) glycosaminoglycan, have been correlated with poor clinical outcome in several malignancies, including breast cancer.
Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos   +9 more
doaj   +1 more source