Results 101 to 110 of about 10,590 (199)

Replacement‐Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions

Aging Cell, Volume 25, Issue 5, May 2026.
We propose a roadmap to guide the development of rejuvenation therapeutics integrating replacement‐based ageing interventions, regeneration, and synthetic technologies that remove or export hundreds of types of molecular, organellar, and cellular damage.
Bjorn Fraser Olaisen, Vadim N. Gladyshev, Bohan Zhang, Anthony Atala, Kyle M. Loh, Vera Gorbunova, Thomas A. Rando, Tony Wyss‐Coray, Eric Verdin, Alexander Zhavoronkov, Morten Scheibye‐Knudsen, Sierra Lore, Daniela Bakula   +12 more
wiley   +1 more source

Endothelial Glycocalyx, Mucin, and Glycan: A Hierarchical Synthesis From Molecular Building Blocks to Supramolecular Functional Barriers

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Glycans encode molecular information, but the endothelial glycocalyx is an organized, multicomponent supramolecular structure whose architecture integrates glycan cues into coherent vascular responses in vivo. The vascular endothelial glycocalyx (eGCX) is a flow‐conditioned, membrane‐coupled surface layer that mediates mechanotransduction ...
Hiroyuki Tomita, Akio Suzuki, Hideshi Okada   +2 more
wiley   +1 more source

New insights into the pathobiology of Down syndrome--hyaluronan synthase-2 overexpression is regulated by collagen VI α2 chain. [PDF]

, 2013
Down syndrome (DS) is a common birth defect characterized by the trisomy of chromosome 21. DS-affected umbilical cords (UCs) of fetuses show altered architecture of the extracellular matrix. Overexpression of the chromosome 21 genes encoding the collagen
Manuela Viola, Karamanos, Nikos K., Stachtea, X., Passi, Alberto, Moretto, P., Xanthi Stachtea, Nikos K. Karamanos, De Luca, Giancarlo, Karousou, Evgenia, Alberto Passi, D'Angelo, M. L., Vigetti, Davide, Stachtea, Xanthi, Maria Luisa D'Angelo, Pallotti, Francesco, Raio, Luigi, Giancarlo De Luca, Moretto, Paola, Raio, L., Viola, Manuela, Karamanos, N. K., Evgenia Karousou, Paola Moretto, D'Angelo, Maria Luisa, Luigi Raio, Francesco Pallotti, Ghezzi, Fabio, Davide Vigetti, Fabio Ghezzi   +28 more
core   +1 more source

Clinical significance of hyaluronan levels and its pro-osteogenic effect on mesenchymal stromal cells in myelodysplastic syndromes

Journal of Translational Medicine, 2018
Background Hyaluronan (HA), a major component of the extracellular matrix, has been proven to play a crucial role in tumor progression. However, it remains unknown whether HA exerts any effects in myelodysplastic syndromes (MDS).
Cheng-Ming Fei, Juan Guo, You-Shan Zhao, Si-Da Zhao, Qing-Qing Zhen, Lei Shi, Xiao Li, Chun-Kang Chang   +7 more
doaj   +1 more source

Extracellular Matrix Origin Directs Morphogenesis and Gene Regulation in Bioengineered Human Skin

Advanced Healthcare Materials, Volume 15, Issue 15, 17 April 2026.
Fibroblast‐driven production of endogenous extracellular matrix is shown to be essential for guiding transcriptional programs and morphogenesis in biofabricated human skin equivalents. Constructs relying on native, cell‐produced ECM support physiological dermo‐epidermal junction formation and tissue architecture, whereas exogenous matrices promote ...
Francesco Galardo, Giorgia Imparato, Costantino Casale, Francesco Urciuolo, Luca Mannino, Antonio Federico, Dario Greco, Paolo Antonio Netti   +7 more
wiley   +1 more source

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
doaj   +1 more source

Hyaluronic acid−CD44 signaling from decidual stromal cells orchestrates dNK1 differentiation and immune tolerance in early pregnancy

Frontiers in Immunology
IntroductionSpontaneous abortion (SA) is closely associated with immune homeostasis of decidual natural killer (dNK) cells at the maternal-fetal interface, yet how decidual stromal cells (DSCs) educate NK cells remains incompletely understood.
Di Wang, Jiawei Zhu, Qingzhi Wang, Lingyun Shi, Yehua He, Zili Jin, Zili Jin, Wenjun Chen, Xiaocong Chen, Shenjun Chen, Hong Li, Ce Zhang, Rui Zhu, Rui Zhu   +13 more
doaj   +1 more source

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

, 2023
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
NC DOCKS at East Carolina University, Wilson, Emily S., Litwa, Karen   +2 more
core  

Enzymatic production of hyaluronan oligo- and polysaccharides

, 2010
Hyaluronan oligo- and polysaccharides are abundant in the human body. Depending on the chain length, hyaluronan is an important structural component or is involved in influencing cell responses during embryonic development, healing processes ...
Kooy, F.K.
core  

Helicobacter pylori activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis

Gut Microbes
Background Metabolic reprogramming and epigenetic alterations play important roles in driving tumor microenvironment (TME) remodeling and immune evasion in gastric cancer (GC). Histone lactylation links glycolytic metabolism to transcriptional regulation,
Han Chen, Yan Wang, Zizhuang Wang, Wei Su, Yuting Shao, Guoxin Zhang, Zi Wang, Yixin Ge, Xiaoying Zhou   +8 more
doaj   +1 more source