Results 91 to 100 of about 5,143 (259)

Expression of hyaluronan synthases in articular cartilage

Osteoarthritis and Cartilage, 2000
To investigate the mRNA expression profiles of three mammalian hyaluronan synthases (HAS1, HAS2 and HAS3) in chondrocytes from normal (undiseased) animal cartilage and osteoarthritic human cartilage maintained in experimental culture systems and exposed to catabolic or anabolic stimuli provided by cytokines, growth factors and retinoic acid ...
Hiscock, D.R.R., Caterson, B., Flannery, C.R.   +2 more
openaire   +2 more sources

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells [PDF]

, 2014
Background Breast cancer\u2013endothelium interactions provide regulatory signals facilitating tumor progression. The endothelial cells have so far been mainly viewed in the context of tumor perfusion and relatively little is known regarding the effects ...
Barbouri, D., Gialeli, C., Karamanos, N.K., Kletsas, D., Passi, A., Viola, M.   +5 more
core   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Hyaluronan Synthase of Chlorella Virus PBCV-1

Science, 1997
Sequence analysis of the 330-kilobase genome of the virus PBCV-1 that infects a chlorella-like green algae revealed an open reading frame, A98R, with similarity to several hyaluronan synthases. Hyaluronan is an essential polysaccharide found in higher animals as well as in a few pathogenic bacteria. Expression of the A98R
DeAngelis, Paul L., Jing, Wei, Graves, Michael V., Burbank, Dwight E., Van Etten, James L.   +4 more
openaire   +3 more sources

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell Exterior

International Journal of Cell Biology, 2015
Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class I family members include mammalian and streptococcal HASs, the focus of
Paul H. Weigel
doaj   +1 more source

Expression of invasion-related extracellular matrix molecules in human glioblastoma versus intracerebral lung adenocarcinoma metastasis [PDF]

, 2010
Tumor cell invasion into the surrounding brain tissue is mainly responsible for the failure of radical surgical resection, with tumor recurrence in the form of microdisseminated disease.
Bognár, L., Hanzély, Z., Hutóczki, G., Kenyeres, A., Klekner, A., Mikó, E., Petrás, M., Scholtz, B., Tóth, J., Varga, I., Zahuczky, G.   +10 more
core   +1 more source

The Role of Anethole in Reproductive Physiology and In Vitro Biotechnologies—A Review

Reproduction in Domestic Animals, Volume 61, Issue 1, January 2026.
ABSTRACT In vitro reproductive biotechnologies show promise for fertility preservation but still face challenges, including oxidative stress from high oxygen tension, which impairs cell viability and development. Antioxidants have been widely explored to attenuate oxidative stress during culture.
André Luiz da Conceição‐Santos, José Ricardo de Figueiredo   +1 more
wiley   +1 more source

Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts

Respiratory Research, 2018
Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells.
Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight, Jason S. Debley   +8 more
doaj   +1 more source