Results 91 to 100 of about 265,910 (261)

Pan-cancer analysis reveals the potential of hyaluronate synthase as therapeutic targets in human tumors

Heliyon, 2023
Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1,
Xunxia Bao, Juan Ran, Chuifang Kong, Zunxi Wan, Juling Wang, Tengfei Yu, Shengming Ruan, Wenjing Ding, Leiming Xia, Daoxiang Zhang   +9 more
doaj  

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Studies on the sperm reservoir of the pig oviduct [PDF]

, 2003
During sperm transport in the female pig a proportion of spermatozoa are arrested, often for 24 h or more, in a particular segment of the utero-tubal junction (UTJ) and the adjacent tubal isthmus, where a sperm reservoir (SR) is built up.
Tienthai, Paisan
core  

Cell density dependent stimulation of PAI-1 and hyaluronan synthesis by TGF-[béta] in orbital fibroblasts [PDF]

, 2018
L
Berta, Eszter, Erdei, Annamária, Galgóczi, Erika, Gazdag, Annamária, Győry, Ferenc, Jeney, Florence, Katkó, Mónika, M. Nagy, Domonkos, Nagy, Endre V., Steiber, Zita, Ujhelyi, Bernadett   +10 more
core   +1 more source

Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration

Small Structures, EarlyView.
This study successfully develops an injectable, dual‐function nanocomposite hydrogel comprising kartogenin‐loaded aminated hollow mesoporous Prussian blue (NH2‐HMPB) nanozyme (termed NH@K nanozyme) and hyaluronic acid methacrylate (HAMA). NH@K nanozyme rejuvenates the senescent microenvironment by scavenging reactive oxygen species and inhibiting ...
Shu‐Hang He, Zhi‐Han Shen, Ren Zhang, Po‐Lin Liu, Xu‐Ran Li, Qing‐Song Deng, Yu‐Chen Zhang, Ang Wang, Xiao‐Qiu Dou, Shang‐Chun Guo, Shi‐Cong Tao   +10 more
wiley   +1 more source

Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3

Journal of Investigative Dermatology, 2011
Hyaluronan (HA) is an abundant matrix molecule whose functions in the skin remain to be fully defined. To explore the roles of HA in cutaneous injury responses, double-knockout mice (abbreviated as Has1/3 null) that lack two HA synthase enzymes (Has1 and
J. Mack, R. Feldman, N. Itano, K. Kimata, Mark E. Lauer, V. Hascall, E. Maytin   +6 more
semanticscholar   +1 more source

Effect of two different preparations of platelet-rich plasma on synoviocytes [PDF]

, 2014
To analyse the modifications induced by two different platelet-rich plasma (PRP) preparations on osteoarthritis (OA) synoviocytes, by documenting changes in gene expression of factors involved in joint physiopathology.OA synoviocytes were cultured for 7 ...
Alice Roffi, Andrea Facchini, Elisa Assirelli, Elizaveta Kon, Erminia Mariani, Franca Vaccaro, Giuseppe Filardo, Lia Pulsatelli, Maurilio Marcacci   +8 more
core   +1 more source

Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease

United European Gastroenterology Journal, EarlyView.
ABSTRACT Intestinal stricture remains one of the most challenging complications in Crohn's disease, and its underlying mechanisms are poorly understood. Accumulating evidence suggests that gut microbiota is significantly altered in stenotic intestines and may play a key role in the development of fibrogenesis in Crohn's disease.
Caiguang Liu, Rongchang Li, Jing Nie, Jinshen He, Zihao Lin, Xiaomin Wu, Jinyu Tan, Zishan Liu, Longyuan Zhou, Xiaozhi Li, Zhirong Zeng, Minhu Chen, Shixian Hu, Yijun Zhu, Ren Mao   +14 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Hyaluronan is crucial for stem cell differentiation into smooth muscle lineage [PDF]

, 2016
Deciphering the extracellular signals that regulate SMC differentiation from stem cells is vital to further our understanding of the pathogenesis of vascular disease and for development of cell-based therapies and tissue engineering.
Abhold, Bourguignon, Bourguignon, Bourguignon, Brecht, Brizzi, Burdon, Calabro, Chen, Chen, Choudhary, Chung, Clarkin, Cyphert, Eggli, Evanko, Evanko, Evans, Ferreira, Gerecht, Itano, Itano, Itano, Itano, Ito, Kakizaki, Kashima, Keller, Lam, Legg, Li, Liu, Liu, Marquez, Martin, Meran, Moyer, Nilsson, Pasonen-Seppanen, Peattie, Pilarski, Qu, Schraufstatter, Shukla, Simpson, Simpson, Sinha, Solis, Spicer, Spicer, Spicer, Tammi, Tang, Toole, Watt, Weigel, Xiao, Zeng, Zoltan-Jones, Zou   +59 more
core   +1 more source