Results 81 to 90 of about 2,273 (170)

Replacement‐Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions

Aging Cell, Volume 25, Issue 5, May 2026.
We propose a roadmap to guide the development of rejuvenation therapeutics integrating replacement‐based ageing interventions, regeneration, and synthetic technologies that remove or export hundreds of types of molecular, organellar, and cellular damage.
Bjorn Fraser Olaisen, Vadim N. Gladyshev, Bohan Zhang, Anthony Atala, Kyle M. Loh, Vera Gorbunova, Thomas A. Rando, Tony Wyss‐Coray, Eric Verdin, Alexander Zhavoronkov, Morten Scheibye‐Knudsen, Sierra Lore, Daniela Bakula   +12 more
wiley   +1 more source

Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell Exterior

International Journal of Cell Biology, 2015
Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class I family members include mammalian and streptococcal HASs, the focus of
Paul H. Weigel
doaj   +1 more source

Endothelial Glycocalyx, Mucin, and Glycan: A Hierarchical Synthesis From Molecular Building Blocks to Supramolecular Functional Barriers

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Glycans encode molecular information, but the endothelial glycocalyx is an organized, multicomponent supramolecular structure whose architecture integrates glycan cues into coherent vascular responses in vivo. The vascular endothelial glycocalyx (eGCX) is a flow‐conditioned, membrane‐coupled surface layer that mediates mechanotransduction ...
Hiroyuki Tomita, Akio Suzuki, Hideshi Okada   +2 more
wiley   +1 more source

Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts

Respiratory Research, 2018
Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells.
Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight, Jason S. Debley   +8 more
doaj   +1 more source

HAS2 (hyaluronan synthase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Extracellular Matrix Origin Directs Morphogenesis and Gene Regulation in Bioengineered Human Skin

Advanced Healthcare Materials, Volume 15, Issue 15, 17 April 2026.
Fibroblast‐driven production of endogenous extracellular matrix is shown to be essential for guiding transcriptional programs and morphogenesis in biofabricated human skin equivalents. Constructs relying on native, cell‐produced ECM support physiological dermo‐epidermal junction formation and tissue architecture, whereas exogenous matrices promote ...
Francesco Galardo, Giorgia Imparato, Costantino Casale, Francesco Urciuolo, Luca Mannino, Antonio Federico, Dario Greco, Paolo Antonio Netti   +7 more
wiley   +1 more source

SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study

mBio
We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational study, we investigated the role of HA at all stages of COVID-19 disease to map the consequences
Urban Hellman, Ebba Rosendal, Joakim Lehrstrand, Johan Henriksson, Tove Björsell, Alfred Wennemo, Max Hahn, Björn Österberg, Luiza Dorofte, Emma Nilsson, Mattias N. E. Forsell, Anna Smed-Sörensen, Anna Lange, Mats G. Karlsson, Clas Ahlm, Anders Blomberg, Sara Cajander, Ulf Ahlgren, Alicia Lind, Johan Normark, Anna K. Överby, Annasara Lenman   +21 more
doaj   +1 more source

Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases

International Journal of Cell Biology, 2015
The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS).
Larry S. Sherman, Steven Matsumoto, Weiping Su, Taasin Srivastava, Stephen A. Back   +4 more
doaj   +1 more source

Hyaluronan Synthases [PDF]

Journal of Biological Chemistry, 1997
P H, Weigel, V C, Hascall, M, Tammi
openaire   +2 more sources

Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3. [PDF]

Am J Pathol, 2022
Wang Y, Mack JA, Hascall VC, Maytin EV.
europepmc   +1 more source