Results 91 to 100 of about 2,273 (170)

Peritoneal Adhesion and Angiogenesis in Ovarian Carcinoma Are Inversely Regulated by Hyaluronan: The Role of Gonadotropins

Neoplasia: An International Journal for Oncology Research, 2010
Ovarian carcinoma is the leading cause of death among gynecologic cancers. Although transformation of the outer ovarian epithelium was linked with ovulation, the disease is significantly more prevalent and severe in postmenopausal women.
Yael Chagit Tzuman, Stav Sapoznik, Dorit Granot, Nava Nevo, Michal Neeman   +4 more
doaj   +1 more source

Role of the extracellular matrix in variations of invasive pathways in lung cancers

Brazilian Journal of Medical and Biological Research, 2013
Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix.
V.K. de Sa, L. Carvalho, A. Gomes, A. Alarcao, M.R. Silva, P. Couceiro, V. Sousa, F.A. Soares, V.L. Capelozzi   +8 more
doaj   +1 more source

Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model

Current Issues in Molecular Biology
Skin radiance is crucial for enhancing facial attractiveness and is negatively affected by factors like hyperpigmentation and aging-related changes. Current treatments often lack comprehensive solutions for improving skin radiance.
Hyeyeon Chun, Hyejin Lee, Jongwook Kim, Hyerin Yeo, Kyongeun Hyung, Dayoung Song, Moonju Kim, Seung-Hyun Jun, Nae-Gyu Kang   +8 more
doaj   +1 more source

Potential Skin Health Benefits of Abalone By-Products Suggested by Their Effects on MAPKS and PI3K/AKT/NF-kB Signaling Pathways in HDF and HaCaT Cells

Foods
Abalone, a marine edible gastropod with nutritional value, is a popular seafood delicacy worldwide, especially in Asia; however, viscera by-products are generally discarded during processing. Therefore, we investigated the skin health benefits of abalone
Eun-A Kim, Nalae Kang, Jun-Ho Heo, Areumi Park, Seong-Yeong Heo, Chang-Ik Ko, Yong-Seok Ahn, Ginnae Ahn, Soo-Jin Heo   +8 more
doaj   +1 more source

Enzyme variants in biosynthesis and biological assessment of different molecular weight hyaluronan

AMB Express
In the present study, low- and high-molecular-weight hyaluronic acids (LMW-HA and HMW-HA) were synthesized in vitro by truncated Streptococcus equisimilis hyaluronan synthases (SeHAS). The enzyme kinetic parameters were determined for each enzyme variant.
Tahereh Ebrahimi, Malihe Keramati, Farnaz Khodabakhsh, Reza Ahangari Cohan   +3 more
doaj   +1 more source

An Engineered Hyaluronan Synthase [PDF]

Journal of Biological Chemistry, 2004
Hiroko Hoshi, Hiroaki Nakagawa, Susumu Nishiguchi, Kazumichi Iwata, Kenichi Niikura, Kenji Monde, Shin-Ichiro Nishimura   +6 more
openaire   +1 more source

An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.

The Journal of biological chemistry, 2004
The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Hiroko, Hoshi, Hiroaki, Nakagawa, Susumu, Nishiguchi, Kazumichi, Iwata, Kenichi, Niikura, Kenji, Monde, Shin-Ichiro, Nishimura   +6 more
openaire   +1 more source

Hyaluronan Synthase 2 [PDF]

, 2020
openaire   +1 more source

Transcriptional regulation of the human hyaluronan synthase genes: focus on hyaluronan synthase 2 [PDF]

This thesis examines the transcriptional regulation of the human hyaluronan synthase (HAS) genes, with particular focus on hyaluronan synthase 2. The data details the reconstruction of the genomic structures of each HAS isoform for the first time, as well as analysis of the activity of each HAS proximal promoter.
openaire  

Insights into substrate binding and utilization by hyaluronan synthase. [PDF]

Elife
Stephens Z, Karasinska J, Zimmer J.
europepmc   +1 more source