Results 71 to 80 of about 2,278 (170)

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, Volume 56, Issue 7, Page 769-783, July 2026.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts

Respiratory Research, 2018
Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells.
Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight, Jason S. Debley   +8 more
doaj   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study

mBio
We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational study, we investigated the role of HA at all stages of COVID-19 disease to map the consequences
Urban Hellman, Ebba Rosendal, Joakim Lehrstrand, Johan Henriksson, Tove Björsell, Alfred Wennemo, Max Hahn, Björn Österberg, Luiza Dorofte, Emma Nilsson, Mattias N. E. Forsell, Anna Smed-Sörensen, Anna Lange, Mats G. Karlsson, Clas Ahlm, Anders Blomberg, Sara Cajander, Ulf Ahlgren, Alicia Lind, Johan Normark, Anna K. Överby, Annasara Lenman   +21 more
doaj   +1 more source

Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases

International Journal of Cell Biology, 2015
The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS).
Larry S. Sherman, Steven Matsumoto, Weiping Su, Taasin Srivastava, Stephen A. Back   +4 more
doaj   +1 more source

Hyaluronan Synthases [PDF]

Journal of Biological Chemistry, 1997
P H, Weigel, V C, Hascall, M, Tammi
openaire   +2 more sources

HAS2 (hyaluronan synthase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3. [PDF]

Am J Pathol, 2022
Wang Y, Mack JA, Hascall VC, Maytin EV.
europepmc   +1 more source

Peritoneal Adhesion and Angiogenesis in Ovarian Carcinoma Are Inversely Regulated by Hyaluronan: The Role of Gonadotropins

Neoplasia: An International Journal for Oncology Research, 2010
Ovarian carcinoma is the leading cause of death among gynecologic cancers. Although transformation of the outer ovarian epithelium was linked with ovulation, the disease is significantly more prevalent and severe in postmenopausal women.
Yael Chagit Tzuman, Stav Sapoznik, Dorit Granot, Nava Nevo, Michal Neeman   +4 more
doaj   +1 more source

Role of the extracellular matrix in variations of invasive pathways in lung cancers

Brazilian Journal of Medical and Biological Research, 2013
Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix.
V.K. de Sa, L. Carvalho, A. Gomes, A. Alarcao, M.R. Silva, P. Couceiro, V. Sousa, F.A. Soares, V.L. Capelozzi   +8 more
doaj   +1 more source