Results 111 to 120 of about 265,910 (261)

Fibrotic Fortresses and Therapeutic Frontiers: Pancreatic Stellate Cells and the Extracellular Matrix in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by a unique tumor microenvironment (TME) that plays pivotal roles in cancer progression, angiogenesis, metastasis, and drug resistance. This complex and dynamic ecosystem comprises cancer cells, stromal cells, and extracellular matrix (ECM) components, which interact ...
Sila Sigirli, Didem Karakas
wiley   +1 more source

Differential Effect of Transforming Growth Factor β (TGF-β) on the Genes Encoding Hyaluronan Synthases and Utilization of the p38 MAPK Pathway in TGF-β-induced Hyaluronan Synthase 1 Activation*

Journal of Biological Chemistry, 2004
Unfettered hyaluronan (HA) production is a hallmark of rheumatoid arthritis. The discovery of three genes encoding hyaluronan synthases (HASs) allows for the investigation of the signaling pathways leading to the activation of these genes.
K. Stuhlmeier, C. Pollaschek
semanticscholar   +1 more source

No jacket required – new fungal lineage defies dress code [PDF]

, 2012
Analyses of environmental DNAs have provided tantalizing evidence for “rozellida” or “cryptomycota”, a clade of mostly undescribed and deeply diverging aquatic fungi. Here, we put cryptomycota into perspective through consideration of Rozella , the only
Abramczyk, Amaral-Zettler, Amend, Aronson, Barr, Bass, Bland, Bowman, Bulawa, Choquer, Dawson, Edgar, Fierer, Fortin, Franzen, Frohlich-Nowoisky, Guerriero, Held, Held, Held, Held, Hibbett, Hibbett, Humber, Itoh, James, Jing, Jones, Jones, Jumpponen, Karling, Keeling, Kim, Kirk, Lacey, Lara, Le Calvez, Leal-Morales, Lefranc, Lefèvre, Lefèvre, Lehninger, Lenardon, Lepere, Lesaulnier, Lopez, Lutzoni, Mangot, Marchler-Bauer, Marshall, Mohamed, Munro, Nagahama, Nagano, Not, O'Brien, Pendland, Porter, Porter, Powell, Qu, Roncero, Ruiz-Herrera, Ruiz-Herrera, Ruiz-Trillo, Schadt, Sekimoto, Shanor, Slapeta, Smith, Sparrow, Stajich, Steenkamp, Stoeck, Takishita, Treitschke, Tsuizaki, van Hannen, Vandenkoornhuyse, Whisler, Wolf   +80 more
core   +1 more source

Mediators of Inflammation and Their Effect on Resident Renal Cells: Implications in Lupus Nephritis [PDF]

, 2013
published_or_final_versio
Chan, DTM, Cheung, KF, Yung, SSY, Zhang, Q   +3 more
core   +1 more source

Complicated Hyaluronan Patterns in Skin: Enlightenment by UVB? [PDF]

, 2007
Hyaluronan has a complex metabolism with rapid turnover in skin, with wide differences occurring in dermal and epidermal compartments. Analyses of acute UVB irradiation of skin, as documented in cultured human fibroblast and immortalized keratinocyte ...
Stern, Robert
core   +1 more source

Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell Exterior

International Journal of Cell Biology, 2015
Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class I family members include mammalian and streptococcal HASs, the focus of
Paul H. Weigel
doaj   +1 more source

TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiology has not been studied.
Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin   +4 more
wiley   +1 more source

Loss of hyaluronan synthases impacts bone morphology, quality, and mechanical properties.

Bone, 2023
Meghana Pendyala, Samuel J. Stephen, D. Vashishth, E. Blaber, D. Chan   +4 more
semanticscholar   +1 more source

Kinetic Characterization of the Recombinant Hyaluronan Synthases from Streptococcus pyogenes and Streptococcus equisimilis *

Journal of Biological Chemistry, 1999
The two hyaluronan synthases (HASs) fromStreptococcus pyogenes (spHAS) and Streptococcus equisimilis (seHAS) were expressed in Escherichia coli as recombinant proteins containing His6 tails. The accompanying paper has described the purification and lipid
V. L. Tlapak-Simmons, B. Baggenstoss, K. Kumari, C. Heldermon, P. Weigel   +4 more
semanticscholar   +1 more source

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Sher Singh, Wan-Jiung(Wan-Chung) Hu, Yu-Ting Yen   +4 more
core   +1 more source