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Mammalian Hyaluronan Synthases [PDF]

IUBMB Life, 2002
AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki Itano, Koji Kimata
exaly   +3 more sources

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Role of hyaluronan and hyaluronan synthase in endometrial cancer

Oncology Reports, 2005
The aim of this study was to determine if the immunohistochemical expression of hyaluronan synthase (HAS) and serum levels of hyaluronan correlate with the clinicopathological manifestations of endometrial carcinoma. Sera were obtained from 59 endometrial cancer patients and 22 post-menopausal healthy women.
Hiromitsu, Yabushita, Tameko, Kishida, Kanako, Fusano, Kouhei, Kanyama, Lisheng, Zhuo, Naoki, Itano, Koji, Kimata, Masayoshi, Noguchi   +7 more
openaire   +2 more sources

Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer

Current Drug Target -Cardiovascular & Hematological Disorders, 2005
Current models of oncogenesis describe cancer as a progression of genetic mutations in a tumor cell mass. However, tumors are more than a clonal expansion of malignant cells. Tumors are heterogeneous, with a complex 3D structure, analogous to organs comprised of different tissues.
Sophia, Adamia, Christopher A, Maxwell, Linda M, Pilarski   +2 more
openaire   +4 more sources

The Hyaluronan Synthase Catalyzes the Synthesis and Membrane Translocation of Hyaluronan

Journal of Molecular Biology, 2012
Hyaluronan (HA), an extracellular linear polysaccharide of alternating N-acetyl-glucosamine and glucuronic acid residues, is ubiquitously expressed in vertebrates, where it affects a broad spectrum of physiological processes, including cell adhesion, migration and differentiation. The HA polymer is synthesized on the cytosolic side of the cell membrane
Caitlin, Hubbard, Joshua T, McNamara, Caleigh, Azumaya, Mehul S, Patel, Jochen, Zimmer   +4 more
openaire   +2 more sources

Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis

Biochemical and Biophysical Research Communications, 2020
Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) on the synthesis of hyaluronan (HA) in human skin fibroblasts and found that TPA and 4-MU have
Kosuke Kasai, Yoshiyuki Kuroda, Yutaro Takabuchi, Akihide Nitta, Takashi Kobayashi, Hiroyuki Nozaka, Tomisato Miura, Toshiya Nakamura   +7 more
openaire   +2 more sources

Analysis of Hyaluronan Synthase Activity

2014
Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As HA modulates several functions (i.e., cell proliferation and migration, inflammation), its presence in the tissues can have positive or negative effects.
Davide, Vigetti, Evgenia, Karousou, Manuela, Viola, Alberto, Passi   +3 more
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Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars

Journal of Molecular Histology, 2016
Hyaluronan (HA) and hyaluronan synthases (HASs) have been shown to play critical roles in embryogenesis and organ development. However, there have not been any studies examining HA and HAS expression and localization during tooth development. The present study was designed to investigate the expression of HA and three isoforms of HASs (HAS1, 2, 3) in ...
Guofeng, Yang, Beizhan, Jiang, Wenping, Cai, Shangfeng, Liu, Shouliang, Zhao   +4 more
openaire   +2 more sources

Hyaluronan synthase expression in ovarian cancer

Oncology Reports, 2004
To determine if the immunohistochemical expression of hyaluronan synthase (HAS) correlates with the clinicopathological manifestations or clinical outcomes of ovarian carcinoma, sections of tumor tissue from 33 ovarian cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 ...
Hiromitsu, Yabushita, Mari, Noguchi, Tameko, Kishida, Kanako, Fusano, Yasuyuki, Noguchi, Naoki, Itano, Koji, Kimata, Masayoshi, Noguchi   +7 more
openaire   +2 more sources

Hyaluronan Synthases Posttranslational Regulation in Cancer

2014
Hyaluronan (HA) is a critical component of cancer microenvironment that is known to increase tumor progression and aggressiveness. The synthesis of HA starts from the cytosolic precursors UDP-N-acetylglucosamine and UDP-glucuronic acid. These two sugar nucleotides have several functions in addition to glycoconjugate synthesis and glucuronidation ...
VIGETTI, DAVIDE, PASSI, ALBERTO
openaire   +3 more sources

Hyaluronan synthases and hyaluronidases in nasal polyps

European Archives of Oto-Rhino-Laryngology, 2015
Nasal polyps (NPs) are benign lesions of nasal and paranasal sinuses mucosa affecting 1-4 % of all adults. Nasal polyposis affects the quality of patient's life as it causes nasal obstruction, postnasal drainage, purulent nasal discharge, hyposmia or anosmia, chronic sinusitis, facial pain and snoring.
T, Panogeorgou, E, Tserbini, S, Filou, D H, Vynios, S S, Naxakis, T A, Papadas, P D, Goumas, N S, Mastronikolis   +7 more
openaire   +2 more sources