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Molecular Cloning of Human Hyaluronan Synthase
Biochemical and Biophysical Research Communications, 1996We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated ...
N, Itano, K, Kimata
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Therapeutic roles of hyaluronan and synthases in cartilage
Trends in Molecular MedicineHyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the role of HAS in matrix assembly, inflammation and the pathogenesis of osteoarthritis (OA).
Gengyun, Le-Chan +4 more
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2009
Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
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Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
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Expression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.
Anticancer research, 2004Hyaluronan is one of the main components of the extracellular matrix. It is synthesized at the cell plasma membrane by specific hyaluronan synthases (HAS). Although a large number of studies have described hyaluronan in pleural effusion from malignant mesothelioma, the source of hyaluronan in malignant mesothelioma has been subject to controversy.The ...
Zhiwen, Liu +3 more
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Eukaryotic Hyaluronan Synthases
Glycoforum, 1998Spicer, Andrew P., McDonald, John A.
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Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2003
Naoki, Itano, Koji, Kimata
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Naoki, Itano, Koji, Kimata
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