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Therapeutic roles of hyaluronan and synthases in cartilage
Trends in Molecular MedicineHyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the role of HAS in matrix assembly, inflammation and the pathogenesis of osteoarthritis (OA).
Gengyun, Le-Chan +4 more
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Expression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.
Anticancer research, 2004Hyaluronan is one of the main components of the extracellular matrix. It is synthesized at the cell plasma membrane by specific hyaluronan synthases (HAS). Although a large number of studies have described hyaluronan in pleural effusion from malignant mesothelioma, the source of hyaluronan in malignant mesothelioma has been subject to controversy.The ...
Zhiwen, Liu +3 more
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Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2003
Naoki, Itano, Koji, Kimata
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Naoki, Itano, Koji, Kimata
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Eukaryotic Hyaluronan Synthases
Glycoforum, 1998Spicer, Andrew P., McDonald, John A.
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Regulated gene expression of hyaluronan synthases during Xenopus laevis development
Gene Expression Patterns, 2004Rosalba Gornati +2 more
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Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line
Matrix Biology, 2006Sharon Byers
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