Results 121 to 130 of about 265,910 (261)
Human leukaemic cell lines synthesize hyaluronan to avoid senescence and resist chemotherapy [PDF]
, 2013 Hyaluronan (HA) is one of the major components of the extracellular matrix. Several solid tumors produce high levels of HA, which promotes survival and multidrug resistance (MDR). HA oligomers (oHAs) can block HA effects.
Alvarez Carbonetto, Elida M. del C. +4 more
core +1 more source
Respiratory Research, 2018 Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells.
Stephen R. Reeves +8 more
doaj +1 more source
Advanced Science, Volume 12, Issue 18, May 15, 2025.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Journal of Biological Chemistry, 1999 The two hyaluronan synthases (HASs) from Streptococcus pyogenes (spHAS) and Streptococcus equisimilis (seHAS) were expressed in Escherichia coli as recombinant proteins containing His6 tails.
V. L. Tlapak-Simmons +3 more
semanticscholar +1 more source
Brain and Behavior, Volume 15, Issue 5, May 2025.The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li +10 more
wiley +1 more source
Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases
International Journal of Cell Biology, 2015 The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS).
Larry S. Sherman +4 more
doaj +1 more source
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction [PDF]
, 2004 Hyaluronan is a major molecule in joint fluid and plays a crucial role in joint motion and the maintenance of joint homeostasis. The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid
Fujii, Katsuyuki +6 more
core +2 more sources
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]
, 2017 Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz +88 more
core +2 more sources
Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3. [PDF]
Am J Pathol, 2022 Wang Y, Mack JA, Hascall VC, Maytin EV.
europepmc +1 more source