Results 51 to 60 of about 265,910 (261)
Hyaluronan Synthase 3 Regulates Hyaluronan Synthesis in Cultured Human Keratinocytes [PDF]
Journal of Investigative Dermatology, 2002 Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
Tetsuya Sayo +7 more
openaire +3 more sources
The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc [PDF]
, 2014 Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space.
Hanson, R.W. +8 more
core +1 more source
The role of hyaluronan in renal cell carcinoma
Frontiers in Immunology, 2023 Renal cell carcinoma (RCC) is associated with high mortality rates worldwide and survival among RCC patients has not improved significantly in the past few years.
Chenchen Jin, Yunfeng Zong
doaj +1 more source
Hyaluronan synthase in trabecular meshwork cells [PDF]
British Journal of Ophthalmology, 2003 Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
Tomohiko Usui +8 more
openaire +2 more sources
Chain Gangs: New Aspects of Hyaluronan Metabolism
Biochemistry Research International, 2012 Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
doaj +1 more source
BMC Cancer, 2018 Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen +5 more
doaj +1 more source
Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]
, 2017 An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A +5 more
core +1 more source
Cancer Cell International, 2021 Background Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency.
Mingzhu Li +5 more
doaj +1 more source
Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms [PDF]
, 2016 Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic acid and N-acetylglucosamine.
Carvalho, Lucas Silva +5 more
core +2 more sources
Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
International Journal of Cell Biology, 2015 Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix.
Kirsi Rilla, Arto Koistinen
doaj +1 more source