Results 61 to 70 of about 265,910 (261)
The control and importance of hyaluronan synthase expression in palatogenesis [PDF]
Frontiers in Physiology, 2013 Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation, and apoptosis. Palatal shelf elevation is considered to be driven by regional accumulation and hydration of glycosoaminoglycans, principally hyaluronan (HA), which provides an intrinsic shelf force ...
Galloway, Jennifer L +3 more
openaire +5 more sources
Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan. [PDF]
PLoS ONE, 2010 Hyaluronan (HA) is a glycosaminoglycan located in the interstitial space which is essential for both structural and cell regulatory functions in connective tissue.
Urban Hellman +7 more
doaj +1 more source
Frontiers in Pharmacology, 2023 The purpose of this study was to illuminate the mechanism by which Schizonepeta tenuifolia Briq. (ST) ethanolic extract prevents skin photoaging in HR-1 hairless mice (HR-1). The ST ethanolic extract alleviated wrinkle formation, epidermal skin thickness,
Min Ji Gu +9 more
doaj +1 more source
Differential Regulation by IL-1β and EGF of Expression of Three Different Hyaluronan Synthases in Oral Mucosal Epithelial Cells and Fibroblasts and Dermal Fibroblasts: Quantitative Analysis Using Real-Time RT-PCR [PDF]
, 2004 Using “real-time RT-PCR”, we assessed the expression of three different hyaluronan synthase genes, HAS1, HAS2, and HAS3, by measuring their mRNA amounts in cultured human oral mucosal epithelial (COME) cells, oral mucosal fibroblasts, and dermal ...
Hata, Ken-ichiro +4 more
core +1 more source
Molecular Identification of a Putative Human Hyaluronan Synthase [PDF]
Journal of Biological Chemistry, 1996 To identify the putative mammalian hyaluronan synthase, we cloned a human cDNA that is related to the Streptococcus hyaluronan synthase (HasA) and the Xenopus developmental protein DG42 which has been shown to have chitin synthase activity. The cDNA, for which we propose the name Has2, encodes a novel protein with a predicted molecular mass of 63.6 kDa.
Yu Yamaguchi, Ken Watanabe
openaire +3 more sources
Hyaluronan: Biosynthesis and signaling [PDF]
, 2014 Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G. +5 more
core +1 more source
Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions [PDF]
Frontiers in Immunology, 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity.
Siiskonen, Hanna +3 more
openaire +5 more sources
Cancer Microenvironment and Inflammation: Role of Hyaluronan [PDF]
, 2015 The role of inflammation in the development of cancer was described as early as 19th century. Abundant evidence supports the preposition that various cancers are triggered by infection and chronic inflammatory disease whereas, evading immune destruction ...
Aikaterini Berdiaki +4 more
core +2 more sources
Disease Models & Mechanisms, 2019 Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that predominantly affects male smokers or ex-smokers and it has a mortality rate of 55% and a median survival of 5 years.
Scott D. Collum +18 more
doaj +1 more source
Cosmetics, 2022 Skin aging is a biological process leading to visible skin alterations. The mechanism of action, clinical efficacy and tolerance of a novel anti-wrinkle technology were evaluated in two skin care products formulated for different skin types.
Vinay Bhardwaj +5 more
doaj +1 more source