Results 71 to 80 of about 5,143 (259)

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis [PDF]

Science Translational Medicine, 2019
Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
Yoon Mee Yang, Mazen Noureddin, Cheng Liu, Koichiro Ohashi, So Yeon Kim, Divya Ramnath, Elizabeth E. Powell, Matthew J. Sweet, Yoon Seok Roh, I-Fang Hsin, Nan Deng, Zhenqiu Liu, Jiurong Liang, Edward Mena, Daniel Shouhed, Robert F. Schwabe, Dianhua Jiang, Shelly C. Lu, Paul W. Noble, Ekihiro Seki   +19 more
openaire   +4 more sources

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells. [PDF]

PLoS ONE, 2012
Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene, suggest that HA and ...
Kate E Keller, Ying Ying Sun, Janice A Vranka, Lauren Hayashi, Ted S Acott   +4 more
doaj   +1 more source

The use of human adipose-derived stem cells in the treatment of physiological and pathological vulvar dystrophies [PDF]

, 2016
“Vulvar dystrophy” is characterized by chronic alterations of vulvar trophism, occurring in both physiological (menopause) and pathological (lichen sclerosus, vulvar graft-versus-host disease) conditions.
CARELLA, SARA, CECCARELLI, SIMONA, MARCHESE, Cinzia, ONESTI, Maria Giuseppina, SCUDERI, Nicolo'   +4 more
core   +4 more sources

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review

International Journal of Dermatology, EarlyView.
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Marie‐Eline Pauline Henriette Debeuf, Maartje Hendrika Pieternel Rauwenhoff, Michel van Geel, Peter Martin Steijlen, Valerie Lydie Roland Marc Verstraeten   +4 more
wiley   +1 more source

Human leukaemic cell lines synthesize hyaluronan to avoid senescence and resist chemotherapy [PDF]

, 2013
Hyaluronan (HA) is one of the major components of the extracellular matrix. Several solid tumors produce high levels of HA, which promotes survival and multidrug resistance (MDR). HA oligomers (oHAs) can block HA effects.
Alvarez Carbonetto, Elida M. del C., Hajos, Silvia Elvira, Lompardía, Silvina Laura, Mascaró, Marilina, Papademetrio, Daniela Laura   +4 more
core   +1 more source

Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco

Plant Biotechnology Journal, EarlyView.
ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes, Omar Sandoval‐Ibáñez, Stéphanie Arrivault, David Rolo, F. Vanessa Loiacono, Alexander Erban, Daniel Karcher, Stephan Obst, Stephanie Ruf, Joachim Kopka, Ralph Bock   +10 more
wiley   +1 more source

Studies on the sperm reservoir of the pig oviduct [PDF]

, 2003
During sperm transport in the female pig a proportion of spermatozoa are arrested, often for 24 h or more, in a particular segment of the utero-tubal junction (UTJ) and the adjacent tubal isthmus, where a sperm reservoir (SR) is built up.
Tienthai, Paisan
core  

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]

, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz, Baig, Banerjee, Baranova, Barritt, Beebe, Beurdeley, Blosa, Bradbury, Brakebusch, Brückner, Brückner, Bukalo, Bukalo, Cabungcal, Caillard, Carstens, Carulli, Carulli, Carulli, Chang, Cheah, Corvetti, Coulson-Thomas, Dauth, Day, de Winter, Deepa, Deepa, Dick, Dityatev, Donato, Favuzzi, Foscarin, Frischknecht, Galtrey, Galtrey, Geissler, Giamanco, Gogolla, Grøndahl, Gu, Gurevicius, Happel, Heleen M. van 't Spijker, Hensch, Hisaoka, Hylin, Härtig, Härtig, Jansen, Jessica C. F. Kwok, Kochlamazashvili, Kwok, Kwok, Lafarga, Lander, Lee, Lensjø, Lensjø, Mabuchi, Matthews, McRae, Miyata, Miyata, Miyata, Morawski, Morawski, Morawski, Morikawa, Orlando, Pantazopoulos, Pelkey, Pizzorusso, Pizzorusso, Romberg, Rossier, Shinozaki, Smith, Spatazza, Spreafico, Steullet, Sugiyama, Suttkus, Suzuki, Vo, Wang, Yamada, Ye   +88 more
core   +2 more sources

Hyaluronan Biosynthesis by Class I Streptococcal Hyaluronan Synthases Occurs at the Reducing End [PDF]

Journal of Biological Chemistry, 2005
Previous studies reached different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA) by addition to the reducing or the nonreducing end. Here we used two strategies to determine the direction of HA synthesis by purified class I HASs from Streptococcus equisimilis and Streptococcus pyogenes.
Valarie L, Tlapak-Simmons, Christina A, Baron, Russell, Gotschall, Dewan, Haque, William M, Canfield, Paul H, Weigel   +5 more
openaire   +2 more sources