Results 81 to 90 of about 2,588 (196)
International Journal of Cell Biology, 2015 Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class I family members include mammalian and streptococcal HASs, the focus of
Paul H. Weigel
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Respiratory Research, 2018 Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment and retention of inflammatory cells.
Stephen R. Reeves +8 more
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International Journal of Gynecology &Obstetrics, Volume 170, Issue 1, Page 312-325, July 2025.Abstract Objective To identify potential biomarkers in patients with polycystic ovary syndrome (PCOS) and atherosclerosis, and to explore the common pathologic mechanisms between these two diseases in response to the increased risk of cardiovascular diseases in patients with PCOS.
Lirong Wang +7 more
wiley +1 more source
Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects
Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu +9 more
wiley +1 more source
Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases
International Journal of Cell Biology, 2015 The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS).
Larry S. Sherman +4 more
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Role of the extracellular matrix in variations of invasive pathways in lung cancers
Brazilian Journal of Medical and Biological Research, 2013 Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix.
V.K. de Sa +8 more
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Neoplasia: An International Journal for Oncology Research, 2010 Ovarian carcinoma is the leading cause of death among gynecologic cancers. Although transformation of the outer ovarian epithelium was linked with ovulation, the disease is significantly more prevalent and severe in postmenopausal women.
Yael Chagit Tzuman +4 more
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Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells. [PDF]
Int J Mol Sci, 2021 Reiprich S +3 more
europepmc +1 more source
Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3. [PDF]
Am J Pathol, 2022 Wang Y, Mack JA, Hascall VC, Maytin EV.
europepmc +1 more source