Results 51 to 60 of about 260,089 (296)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Hybrid Baryons, a brief review [PDF]

open access: yes, 2000
This contribution is a brief review of the status of hybrid baryons, which are hypothetical baryons that incorporate a gluonic excitation. We first summarize the status of hybrid mesons, since this closely related topic has seen considerable recent ...
Barnes, T.
core   +3 more sources

Membrane excitability expressed in human neuroblastoma cell hybrids [PDF]

open access: yesFEBS Letters, 1988
The voltage‐sensitive Na+ channel is responsible for the action potential of membrane electrical excitability in neuronal tissue. Three methods were used to demonstrate the presence of neurotoxin‐responsive Na+ channels in two hybrid cell lines resulting from the fusion of excitable human neuroblastoma cells with mouse fibroblasts.
Gilbert, Fred   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

A New Outer-Rotor Hybrid-Excited Flux-Switching Machine Employing the HTS Homopolar Topology

open access: yesEnergies, 2019
Currently, studies of flux switching machines are actively underway owing to several advantages of these machines, including their sturdy rotor structure and high output capability.
Jong Myung Kim   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Ultrafast charge transfer and vibronic coupling in a laser-excited hybrid inorganic/organic interface

open access: yes, 2020
Hybrid interfaces formed by inorganic semiconductors and organic molecules are intriguing materials for opto-electronics. Interfacial charge transfer is primarily responsible for their peculiar electronic structure and optical response.
Cocchi, C.   +5 more
core   +1 more source

Redundant neural vision systems: competing for collision recognition roles [PDF]

open access: yes, 2013
Ability to detect collisions is vital for future robots that interact with humans in complex visual environments. Lobula giant movement detectors (LGMD) and directional selective neurons (DSNs) are two types of identified neurons found in the visual ...
Rind, F. Claire, Yue, Shigang
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

A Study on the Design of a Fault-Tolerant Consequent-Pole Hybrid Excited Machine for Electric Vehicles

open access: yesWorld Electric Vehicle Journal
In this paper, a new fault-tolerant consequent-pole hybrid excited (FTCPHE) machine with toroidal winding (TW) is designed for electric vehicles (EVs). In this proposed machine, U-type permanent magnets (PMs) are adopted in the consequent-pole rotor with
Guangyu Qu   +3 more
doaj   +1 more source

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