Results 51 to 60 of about 82,588 (292)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Optimum design and research on novel vehicle hybrid excitation synchronous generator

open access: yesMATEC Web of Conferences, 2017
Hybrid excitation is an organic combination of permanent magnet excitation and electric excitation. Hybrid excitation synchronous generator (HESG) both has the advantages of light quality, less losses and high efficiency like permanent magnet generator ...
Liu Zhong-Shu
doaj   +1 more source

Hybrid Excitation PM Synchronous Motors: Part II - Finite Element Analysis

open access: yes, 2021
This paper deals with the finite element analysis of Hybrid Excitation Permanent Magnet Synchronous Motors, that is, synchronous motors characterised by a rotor including both permanent magnets and an excitation winding.
Cinti L., Bianchi N., Michieletto D.
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A Study on the Design of a Fault-Tolerant Consequent-Pole Hybrid Excited Machine for Electric Vehicles

open access: yesWorld Electric Vehicle Journal
In this paper, a new fault-tolerant consequent-pole hybrid excited (FTCPHE) machine with toroidal winding (TW) is designed for electric vehicles (EVs). In this proposed machine, U-type permanent magnets (PMs) are adopted in the consequent-pole rotor with
Guangyu Qu   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

A New Outer-Rotor Hybrid-Excited Flux-Switching Machine Employing the HTS Homopolar Topology

open access: yesEnergies, 2019
Currently, studies of flux switching machines are actively underway owing to several advantages of these machines, including their sturdy rotor structure and high output capability.
Jong Myung Kim   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

High-Precision Optical Excited Heaters Based on Au Nanoparticles and Water-Soluble Porphyrin

open access: yesMetals, 2023
Gold nanoparticles are widely used as local heaters under optical excitation. Hybrid molecular-plasmon nanostructures based on gold nanoparticles and water-soluble porphyrin have been developed.
Alexey V. Povolotskiy   +4 more
doaj   +1 more source

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