Results 61 to 70 of about 1,701,848 (282)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Optimum design and research on novel vehicle hybrid excitation synchronous generator

MATEC Web of Conferences, 2017
Hybrid excitation is an organic combination of permanent magnet excitation and electric excitation. Hybrid excitation synchronous generator (HESG) both has the advantages of light quality, less losses and high efficiency like permanent magnet generator ...
Liu Zhong-Shu
doaj   +1 more source

Hybrid-excited variable reluctance machines [PDF]

2015 Intl Aegean Conference on Electrical Machines & Power Electronics (ACEMP), 2015 Intl Conference on Optimization of Electrical & Electronic Equipment (OPTIM) & 2015 Intl Symposium on Advanced Electromechanical Motion Systems (ELECTROMOTION), 2015
In this paper, a study on the energy conversion and the consequent torque production mechanism in hybrid excited variable reluctance machines (HEVRMs) is presented. The derived torque expressions of single-phase HEVRMs with different switching strategies show a similarity to that of DC machines (DCMs), wound-field synchronous machines (WFSMs), or ...
Lomonova, E.A., Tang, Y., Paulides, J.J.H.   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Sandwich-Type Multi-Degree-of-Freedom Ultrasonic Motor With Hybrid Excitation

IEEE Access, 2016
A sandwich-type multi-degree-of-freedom (MDOF) ultrasonic motor with hybrid excitation is proposed in this paper. The motor adopts pair combination of three resonance modes to drive the sphere rotations around three coordinate axes.
Xiaohui Yang, Yingxiang Liu, Weishan Chen, Junkao Liu   +3 more
doaj   +1 more source

Hybrid Excitation of the Axial Inductor Machine [PDF]

Latvian Journal of Physics and Technical Sciences, 2012
The paper considers the possibility to use permanent magnets in the rotor slots of axial inductor machine with the aim to create a hybrid excitation of such a machine − from the magnets and from the excitation winding which is placed between the stator cores.
S. Orlova, V. Pugachov, N. Levin
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Analysis of an Axial Field Hybrid Excitation Synchronous Generator

Energies
An axial field hybrid excitation synchronous generator (AF-HESG) is proposed for an independent power supply system, and its electromagnetic performance is studied in this paper.
Junyue Yu, Shushu Zhu, Chuang Liu
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source