Results 51 to 60 of about 515,378 (312)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Hybridization among three native North American Canis species in a region of natural sympatry. [PDF]

PLoS ONE, 2008
Population densities of many species throughout the world are changing due to direct persecution as well as anthropogenic habitat modification. These changes may induce or increase the frequency of hybridization among taxa.
Frank Hailer, Jennifer A Leonard
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

An Immuno-Genetic Hybrid Algorithm

International Journal of Computers Communications & Control, 2009
The construction of artificial systems by drawing inspiration from natural systems is not a new idea. The Artificial Neural Network (ANN) and Genetic Algorithms (GAs) are good examples of successful applications of the biological metaphor to the solution of computational problems.
Emad Nabil, Ibrahim Farag, Amr Badr
openaire   +3 more sources

Mapping of Multiple DNA Gains and Losses in Primary Small Cell Lung Carcinomas by Comparative Genomic Hybridization [PDF]

, 1994
Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens.
Cremer, Thomas, Holtgreve-Grez, Heidi, Manoir, Stanislas du, Petersen, Iver, Ried, Thomas, Schröck, Evelin, Speicher, Michael R.   +6 more
core  

Morphometric Variation as an Indicator of Genetic Interactions between Black-capped and Carolina Chickadees at a Contact Zone in the Appalachian Mountains [PDF]

, 2000
We studied hybridization and introgression between Black-capped (Poecile atricapillus) and Carolina (P. carolinensis) chickadees along two transects in the Appalachians using four genetic markers and multivariate analysis of morphology.
Braun, Michael J., Sattler, Gene D.
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Natural and Anthropogenic Hybridization in Two Species of Eastern Brazilian Marmosets (Callithrix jacchus and C. penicillata).

PLoS ONE, 2015
Animal hybridization is well documented, but evolutionary outcomes and conservation priorities often differ for natural and anthropogenic hybrids. Among primates, an order with many endangered species, the two contexts can be hard to disentangle from one
Joanna Malukiewicz, Vanner Boere, Lisieux F Fuzessy, Adriana D Grativol, Ita de Oliveira E Silva, Luiz C M Pereira, Carlos R Ruiz-Miranda, Yuri M Valença, Anne C Stone   +8 more
doaj   +1 more source

Relationship of phenotypic variation and genetic admixture in the Saltmarsh–Nelson\u27s sparrow hybrid zone [PDF]

, 2015
Hybridization is influential in shaping species\u27 dynamics and has many evolutionary and conservation implications. Identification of hybrid individuals typically relies on morphological data, but the assumption that hybrids express intermediate traits
Kovach, Adrienne I., O\u27Brien, Kathleen M., Olsen, Brian J., Shriver, W. Gregory, Walsh, Jennifer   +4 more
core   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source