Results 61 to 70 of about 59,780 (293)
Integrated scFv identification and CAR T cell generation for AML targeting in vivo
International Journal of Cancer, EarlyView.What's New? Acute myeloid leukemia (AML) is a rapidly progressing blood cancer. Advancing chimeric antigen receptor (CAR) T cell therapies, particularly through rapid translation of single chain variable fragment (scFv) discovery into CAR constructs, may improve clinical outcomes, especially the development of patient individualized CAR T cells.
Yi Liu +13 more
wiley +1 more source
V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.
Journal of Immunology, 1993 Anti-Sm autoantibodies are unique to SLE, but are present in only 25% of patients with this disease. This response also occurs at a similar frequency in mice of the autoimmune MRL strains.
D. Bloom +7 more
semanticscholar +1 more source
Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. [PDF]
, 2004 The immunoglobulin kappa light chain intronic enhancer (iEkappa) activates kappa rearrangement and is required to maintain the earlier or more efficient rearrangement of kappa versus lambda (lambda).
Inlay, Matthew A +3 more
core
Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice [PDF]
, 1988 Experimental allergic encephalomyelitis (EAE)' is an autoimmune inflammatory demyelinating disease in the central nervous system (CNS) of animals immunized with myelin basic protein (MBP). The disease is directly mediated by Thelper cells that recognize
Ando, Dale G. +5 more
core +1 more source
Pest Management Science, EarlyView.This study discusses a promising new attractive targeted sugar bait (ATSB) technology using yeast that expresses shRNA targeting essential genes in the fruit pest spotted‐wing drosophila (SWD). The yeast, which is delivered using soda as a sugar bait, could one day be an effective component in integrated SWD control programs.
Keshava Mysore +5 more
wiley +1 more source
Aging Cell, EarlyView.Inhibition of MMP9/13 restores both muSC behaviour and regeneration, while macrophage ablation enhances muSC recruitment to the injury, but fails to improve muscle repair in telomerase‐deficient zebrafish larvae. ABSTRACT Ageing progressively impairs skeletal muscle regeneration, contributing to reduced mobility and quality of life. While the molecular
Yue Yuan, Carlene Dyer, Robert D. Knight
wiley +1 more source
Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas.
Journal of Immunology, 1996 The functional role of reactive oxygen intermediates (ROI) in activation-induced death of mature T lymphocytes and hybridomas was tested using antioxidants and inhibitors of enzymes that generate oxidants. These agents were shown to inhibit TCR-triggered
M. S. Williams, P. Henkart
semanticscholar +1 more source
, 1986 The proliferative capacity of gland cells in Hydra attenuata was investigated. The results indicate that both gland cell proliferation and interstitial cell differentiation to gland cells contribute to the maintenance of the whole population.
David, Charles N., Schmidt, Tobias
core
Aging Cell, EarlyView.Adenine nucleotide translocase 1 (ANT1), a mitochondrial ATP transporter, is decreased in the lung epithelium of aged adults and aged mice correlating to pathogenic airway changes. Loss of ANT1 correlates with increased cellular senescence and changes in COL8A1 in the airway epithelium of the lung.
Roshani Jha +5 more
wiley +1 more source
Allergy, EarlyView.SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy +17 more
wiley +1 more source