Results 81 to 90 of about 17,547 (197)

Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism, mitochondrial function and myogenesis, yet ...
Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel   +12 more
wiley   +1 more source

Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated Rejection

Cells
Donor-specific anti-HLA antibodies (DSAs) bind to donor vascular endothelial cells and mediate allograft rejection (AMR), but a clinical challenge for which targeted therapeutic options remain limited.
Jing Zhang, Leiyan Wei, Lei Song, Xiaofang Lu, Liang Tan, Xin Li, Li Fu, Qizhi Luo, Xubiao Xie, Yizhou Zou   +9 more
doaj   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

hybridoma

, 2014
Citation: 'hybridoma' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.H02875 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, Volume 183, Issue 15, Page 4227-4245, August 2026.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

A First‐In‐Class Antibody Enabling Detection of Altered Peripheral Non‐Phosphorylated Clusterin With Translational Potential in Dementia

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Non‐phosphorylated clusterin is decreased in the serum of dementia patients but not in Parkinson's disease, and phosphorylated clusterin in serum does not originate from the brain. 3D3F10, a monoclonal antibody specific to non‐phosphorylated clusterin, enables modification‐specific detection with diagnostic potential for dementia.
Hejie Li, Yu Li, Wenping Liang, Liyong Wu, Chao Han, Qianxu Ren, Xi Liu, Yanning Cai, Zhe Wang   +8 more
wiley   +1 more source

Metformin Partially Attenuates Simvastatin‐Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Simvastatin induces metabolic suppression, mitochondrial dysfunction, and atrophy‐related responses in skeletal muscle cells. In differentiated C2C12 myotubes, metformin partially attenuates these alterations by preserving myotube structural integrity, reducing cellular stress signaling, and maintaining mitochondrial network organization despite ...
Chuqi He, Mike Wesselink, Jelle Y. Huijts, Zhenjia Zhong, Moritz Eggelbusch, Richard T. Jaspers, Rob C. I. Wüst   +6 more
wiley   +1 more source

Development and Evaluation of Monoclonal Antibodies against CBPP Antigen with the End Goal of Developing an ELISA Kit

Veterinary Medicine International
Contagious bovine pleuropneumonia (CBPP) is an infectious and contagious bacterial respiratory disease that affects cattle with significant economic losses to the African animal industry.
Lorato Ramathudi-Dunbar, Emmanuel Awosanya, Sanne Bodjo Charles, Ethel Chitsungo, Cisse Rahamatou Moustapha Boukary, Nick Nwankpa, Hassen Gelaw, Yebechaye Tessema, Gelagay Melesse A., Richard Rayson Sanga, Adorbley Bright, Jean de Dieu Baziki   +11 more
doaj   +1 more source

Generation of the first monoclonal antibody using mouse hybridomas

Haematologica, 2022
Brunangelo Falini
doaj   +1 more source